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the claim

Amniocentesis carries a measurable risk of miscarriage

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Current systematic reviews and meta-analyses indicate that amniocentesis carries a measurable risk of miscarriage, though modern estimates (generally under 1%) are considerably lower than historical figures.

The analysis

The retrieved literature consistently reports a measurable, albeit low, percentage of miscarriages following amniocentesis. While modern studies emphasize that the procedure-related risk is lower than traditionally quoted (frequently around 0.5% to 1%), the overall risk itself remains measurable and documented across multiple large-scale meta-analyses and cohort studies.

Evidence for · 4
Procedure‐related risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review and meta‐analysis
Recorded source metadata

R. Akolekar, J. Beta, G. Picciarelli, C. Ogilvie, F. D'Antonio. Procedure‐related risk of miscarriage following amniocentesis and chorionic villus sampling: a systematic review and meta‐analysis. 2015. https://doi.org/10.1002/uog.14636

A systematic review and meta-analysis estimated the overall risk of miscarriage prior to 24 weeks following amniocentesis at 0.81%.

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More for · 3
Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta‐analysis
Recorded source metadata

L. Salomon, A. Sotiriadis, C. Wulff, A. Odibo, R. Akolekar. Risk of miscarriage following amniocentesis or chorionic villus sampling: systematic review of literature and updated meta‐analysis. 2019. https://doi.org/10.1002/uog.20353

An updated systematic review and meta-analysis confirmed that amniocentesis carries a measurable, though historically overestimated, risk of procedure-related complications.

Procedure‐related risk of miscarriage following chorionic villus sampling and amniocentesis
Recorded source metadata

J. Beta, W. Zhang, S. Geris, V. Kostiv, R. Akolekar. Procedure‐related risk of miscarriage following chorionic villus sampling and amniocentesis. 2019. https://doi.org/10.1002/uog.20293

A large retrospective cohort study found an amniocentesis miscarriage rate of 0.8%, though noting it was not statistically different from unexposed control groups.

Difference in Procedure-Related Risk of Miscarriage between Early and Mid-Trimester Amniocentesis: A Retrospective Cohort Study
Recorded source metadata

Kelly Steinfort, Ellen Van Houtven, Yves Jacquemyn, Bettina Blaumeiser, Philip Loquet. Difference in Procedure-Related Risk of Miscarriage between Early and Mid-Trimester Amniocentesis: A Retrospective Cohort Study. 2021. https://doi.org/10.3390/diagnostics11061098

A comparative cohort study evaluating early versus mid-trimester amniocentesis reported procedure-related fetal loss rates ranging between 0.36% and 0.82%.

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first checked02 Aug 2026
judged → SUPPORTED · 9202 Aug 2026
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