Nitrobenzene reduces to aniline in catalytic and acidic media through a multi-step intermediate pathway
Evidence from catalytic and acidic media studies supports the multi-step intermediate pathway for the reduction of nitrobenzene to aniline.
The retrieved papers document the reduction of nitrobenzene and related nitroaromatic compounds using various catalytic and acidic or proton-donating conditions, confirming that the process proceeds through stepwise electron and proton transfers involving defined intermediates.
Shizunobu Hashimoto, Koji Kano, Kazuo Ueda. Photochemical Reduction of Nitrobenzene and Its Reduction Intermediates. IX. The Photochemical Reduction of 4-Nitropyridine in a Hydrochloric Acid-Isopropyl Alcohol Solution. 1971. https://doi.org/10.1246/bcsj.44.1102
Paper 3 demonstrates that acidic media promote the protonation and subsequent step-by-step reduction of nitro-compounds through distinct intermediates.
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Dao V, Vuong TH, Nga NK, Mejía E. Phenazine-Based Homogeneous Photocatalysts for Visible-Light-Driven Hydrogenation of Nitroarenes Under Mild Conditions.. 2026. https://doi.org/10.3390/molecules31071063
Paper 7 confirms that the reduction of nitroarenes involves stepwise electron and proton transfer mechanisms forming reactive species.
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