Specific blood types confer differential susceptibility to infectious diseases
Multiple epidemiological studies demonstrate that ABO blood types confer varying levels of susceptibility and severity to infectious diseases like COVID-19 and other respiratory infections, though findings can vary depending on the specific pathogen.
The claim states that specific blood types confer differential susceptibility to infectious diseases. Multiple papers in the provided set support this by demonstrating links between ABO blood groups and susceptibility/severity for infectious conditions such as COVID-19 and respiratory tract diseases (Papers 0, 5, 8, 9, 10). One study found no association with HIV (Paper 11), while the remaining papers (1, 2, 3, 4, 6, 7) discuss type 2 diabetes or blood cancers rather than infectious diseases and are thus tangential. Overall, the preponderance of relevant evidence supports the claim.
Qian Fan, Wei Zhang, Bo Li, Dejia Li, Jian Zhang, Fang Zhao. Association Between ABO Blood Group System and COVID-19 Susceptibility in Wuhan. 2020. https://doi.org/10.3389/fcimb.2020.00404
This study provides epidemiological evidence connecting blood type A to higher susceptibility to COVID-19.
Obeagu Emmanuel Ifeanyi. Association of ABO Blood Group With HIV Infection. 2022. https://doi.org/10.37191/mapsci-jidm-1(1)-001
This cross-sectional study found no statistically significant relationship between ABO blood group antigens and HIV infection.
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Shu Su, Lingxia Guo, Ting Ma, Yang Sun, Aowei Song, Wen-hua Wang, Xi-Wen Gu, Wen-jie Wu, Xinxin Xie, Leilei Zhang, Lei Zhang, Jiangcun Yang. Association of ABO blood group with respiratory diseases hospitalisation and severe outcomes: a retrospective cohort study in blood donors.. 2022. https://doi.org/10.1016/j.ijid.2022.05.019
The retrospective cohort study indicates that ABO blood groups influence the risk of hospitalisation and differential susceptibility for various respiratory diseases.
Meisam Moezzi, Abdolhakim Abarian, Alireza Rafati Navaii, Siamak Baghaei, Somayeh Ataee Rad, Soodabeh Pooromidi, Ehsan Moradi-joo, M. Davarpanah. Assessment of the Relationship between ABO Blood Group and Susceptibility, Severity, and Mortality Rates in COVID-19. 2021. https://doi.org/10.51847/CBpB35jRv7
The study reports a significant relationship showing blood type A individuals face a higher risk of COVID-19 infection and severity, while blood group O has a protective effect.
Radhika Thakkar, I. Rangraze, S. Gabhale, Jagjeewan Ram, Nagaraju Devarapalli, Vishal S. Kudagi, Rahul V. C. Tiwari. Correlation of ABO Blood Group Susceptibility to Disease Severity of SARS-COV-2: An Original Research. 2024. https://doi.org/10.4103/jpbs.jpbs_595_23
Results from this observational study show that blood group A was most frequent in severe COVID-19 cases, supporting a link between blood type and disease severity.
N. Chrysanthakopoulos. Examination of the Relationship between the ABO Blood Group and Susceptibility to SARS-CoV-2 Infection Risk. 2022. https://doi.org/10.33425/2771-9073.1004
This review highlights how ABO blood group polymorphism and anti-A antibodies impact pathogen binding, providing a biological mechanism for differential infection susceptibility.
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