Smokers exhibit altered oxygen saturation values compared to non-smokers
Evidence indicates that tobacco smoking alters oxygen-related blood parameters, such as carboxyhemoglobin and peripheral oxygen saturation, due to carbon monoxide inhalation.
The retrieved literature consistently supports the claim that smokers exhibit altered oxygen saturation and related hematological values. Studies highlight the formation of carboxyhemoglobin, changes in arterial oxygen content, and lower pulse oximetry oxygen saturation (SpO2) values in specific smoking populations, satisfying the criteria for a supported claim.
P. Herath, S. Wimalasekera, T. Amarasekara, M. Fernando, S. Turale. Adverse effects of cigarette smoking on exhaled breath carbon monoxide, blood carboxyhemoglobin, and hematological parameters amongst Sri Lankan adult tobacco smokers: A descriptive study. 2021. https://doi.org/10.18332/popmed/143076
This study demonstrates that tobacco smoking increases carboxyhemoglobin (COHb%) and alters hematological parameters by binding carbon monoxide to hemoglobin.
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Giulia Sartori, A. Fantin, Marcello Ferrari, Ernesto Crisafulli. Association between daytime sleepiness and impaired expiratory lung function due to smoking in patients with mild-to-severe OSA: an observational study. 2025. https://doi.org/10.1007/s11325-025-03530-w
Patients with obstructive sleep apnea who smoke and have impaired expiratory lung function exhibited lower mean oxygen saturation values compared to non-smoking groups.
Alexandros Sotiridis, Charalambos Dardamanis-Aidonas, Anastasios Makris, Ioannis Loukas, N. Geladas, M. Koskolou. Tobacco smoking: a stimulus for blood volume expansion.. 2025. https://doi.org/10.1016/j.resp.2025.104505
Regular tobacco smoking involves inhaling carbon monoxide which binds to hemoglobin, acutely reducing arterial oxygen content and triggering compensatory hematological adjustments.
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