Teeth possess limited capacity for self-repair and healing.
Teeth possess limited capacity for self-repair and healing, particularly regarding enamel and deep dentin-pulp injuries, which typically require clinical intervention to prevent necrosis.
The provided papers consistently support the claim that teeth have a limited capacity for natural self-repair. While dental pulp and dentin can handle minor disruptions or mild insults through defense mechanisms and reparative dentinogenesis, significant damage (such as deep caries or lost enamel) cannot naturally regenerate, necessitating advanced clinical and tissue engineering strategies.
D. Moussa, C. Aparicio. Present and future of tissue engineering scaffolds for dentin-pulp complex regeneration. 2018. https://doi.org/10.1002/term.2769
Paper 0 details how deep tooth decay leads to irreversible pulp damage and notes the critical need for regenerative interventions because natural healing fails to overcome existing limitations.
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Sili Han, Luoyao Wang, Xiu Peng, Jing Wang, Yeling Ou, Y. Tao, Longjiang Ding, Linglin Zhang. Amelogenin-Inspired Autoadaptive Peptide in a Caries Microenvironment Facilitates Long-Term Protection of the Dentin-Pulp Complex.. 2024. https://doi.org/10.1021/acsami.4c07981
Paper 1 notes that while mild disruptions lead to reparative dentin, preserving the dentin-pulp complex generally lacks comprehensive, long-lasting natural solutions without artificial interventions.
Kerstin M Galler, Manuel Weber, Yüksel Korkmaz, Matthias Widbiller, Markus Feuerer. Inflammatory Response Mechanisms of the Dentine-Pulp Complex and the Periapical Tissues.. 2021. https://doi.org/10.3390/ijms22031480
Paper 7 explains that while the dental pulp possesses intricate defense mechanisms, deep carious lesions still lead to tissue necrosis without therapeutic intervention.
Ammar Alghadeer, Sesha Hanson-Drury, Anjali P Patni, Devon D Ehnes, Yan Ting Zhao, Zicong Li, Ashish Phal, Thomas Vincent, Yen C Lim, Diana O'Day, Cailyn H Spurrell, Aishwarya A Gogate, Hai Zhang, Arikketh Devi, Yuliang Wang, Lea Starita, Dan Doherty, Ian A Glass, Jay Shendure, Benjamin S Freedman, David Baker, Mary C Regier, Julie Mathieu, Hannele Ruohola-Baker. Single-cell census of human tooth development enables generation of human enamel.. 2023. https://doi.org/10.1016/j.devcel.2023.07.013
Paper 10 notes that human tooth enamel cannot be naturally regenerated after damage due to a lack of ameloblasts in erupted teeth.
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