SSRI and SNRI medications cause anorgasmia

Eliasz Panek, Damian Jasłowski, Mateusz Rzeszutko, Przemysław Raczkiewicz, Dominika Panasiuk, Mateusz Skrętowicz, Patrycja Szponarowicz, Bartosz Snopkowski, Tomasz Korzec, Jakub Sosnowski. Post-SSRI sexual dysfunction and SSRI induced sexual dysfunction - literature review. 2023. https://doi.org/10.12775/jehs.2023.19.01.007

This review highlights sexual dysfunction as a very common side effect of selective serotonin reuptake inhibitors that can occur both during and after treatment.

Dagostin Ferraz S, Kuyunga L, Rech P, Rodrigues Uggioni ML, Rodrigues Candido AC, Dagostin VS, Silva FR, Colonetti T, Grande AJ, da Rosa MI. Sexual dysfunction associated with selective serotonin reuptake inhibitors in adults with depression: a systematic review and meta-analysis.. 2026. https://doi.org/10.1007/s00228-026-04011-z

This systematic review and meta-analysis of randomized controlled trials establishes that SSRIs are significantly associated with an increased risk of orgasmic dysfunction.

Zini J, Turecki G. Antidepressant-Induced Sexual Dysfunction in Adults: A Targeted Scoping Review and Clinical Update.. 2026. https://doi.org/10.1097/jcp.0000000000002210

This scoping review notes that antidepressant-induced sexual dysfunction is a common and under-recognized adverse effect particularly associated with SSRIs and SNRIs.

Shen M, He L, Chen P, Zhang L, Zeng D, Li Y, Li H. Selective serotonin reuptake inhibitor and serotonin-norepinephrine reuptake inhibitor use and sexual dysfunction: a pharmacovigilance analysis.. 2026. https://doi.org/10.1093/sexmed/qfag008

This pharmacovigilance analysis demonstrates that sexual adverse events, including sexual dysfunction, are associated with various SSRIs and SNRIs in real-world data.