Inhibitory connections between neurons can be strengthened through plasticity

the verdict

SUPPORTED

the evidence backs this

Recorded sources

3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Neuronal inhibitory connections can indeed be strengthened through various forms of plasticity, such as long-term potentiation at inhibitory synapses mediated by receptor modifications and molecular checkpoints.

The analysis

The retrieved papers provide robust experimental and physiological evidence showing that inhibitory synapses can undergo long-term potentiation (iLTP) and other forms of activity-dependent strengthening, supporting the claim.

Evidence for · 3

A physiological role for GABA <sub>A</sub> receptor desensitization – induction of long-term potentiation at inhibitory synapses

Recorded source metadata

Martin Field, Philip Thomas, Trevor G Smart. A physiological role for GABA <sub>A</sub> receptor desensitization – induction of long-term potentiation at inhibitory synapses. 2020. https://doi.org/10.1101/2020.06.02.128900

Demonstrates an enduring form of long-term potentiation at inhibitory synapses that elevates synaptic current amplitude following GABA_A receptor desensitization.

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More for · 2

Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility.

Recorded source metadata

Zhu X, Hagopian LL, Wallquist KE, Sohal VS. Synaptic plasticity of prefrontal long-range inhibition regulates cognitive flexibility.. 2026. https://doi.org/10.1016/j.neuron.2026.04.028

Shows that learning rule shifts potentiate long-range GABAergic synapses from prefrontal parvalbumin-expressing neurons.

Source citation format

Neuroligin-2-Dependent Adhesion Defines a Molecular Checkpoint for Inhibitory Synaptic Plasticity.

Recorded source metadata

Lech A, Wiera G, Mozrzymas JW. Neuroligin-2-Dependent Adhesion Defines a Molecular Checkpoint for Inhibitory Synaptic Plasticity.. 2026. https://doi.org/10.1523/jneurosci.1746-25.2026

Identifies neuroligin-2-dependent adhesion as a critical mediator and molecular checkpoint for inhibitory long-term potentiation.

Source citation format

The paper trail · every fact has a biography

first checked01 Aug 2026

judged → SUPPORTED · 7801 Aug 2026

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