The distance between the ribosome binding site and start codon is critical for prokaryotic translation efficiency

the verdict

SUPPORTED

the evidence backs this

Recorded sources

2 sources for · 0 against

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The distance between the ribosome binding site (Shine-Dalgarno sequence) and the start codon is critical for prokaryotic translation efficiency, as demonstrated by studies showing that improper spacing destabilizes tRNA binding and reduces translocation rates.

The analysis

The claim is a specific, well-established biological principle regarding prokaryotic translation. Papers 1 and 3 provide direct empirical evidence showing that varying the spacer distance between the ribosome binding site and the codon alters translation dynamics, ribosomal complex formation, and translocation rates.

Evidence for · 2

Short spacing between the Shine–Dalgarno sequence and P codon destabilizes codon–anticodon pairing in the P site to promote +1 programmed frameshifting

Recorded source metadata

Aishwarya Devaraj, Kurt Fredrick. Short spacing between the Shine–Dalgarno sequence and P codon destabilizes codon–anticodon pairing in the P site to promote +1 programmed frameshifting. 2010. https://doi.org/10.1111/j.1365-2958.2010.07421.x

Paper 1 demonstrates that altering the spacing between the Shine-Dalgarno sequence and the P codon heavily impacts P-site tRNA binding and complex formation.

Source citation format

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More for · 1

Extending the spacing between the Shine-Dalgarno sequence and P-site codon reduces the rate of mRNA translocation

Recorded source metadata

Hironao Wakabayashi, Chandani Warnasooriya, Dmitri N. Ermolenko. Extending the spacing between the Shine-Dalgarno sequence and P-site codon reduces the rate of mRNA translocation. 2020. https://doi.org/10.1101/2020.04.16.045807

Paper 3 shows that the length of the spacer between the Shine-Dalgarno sequence and the codon strongly affects ribosome translocation and mRNA-ribosome interactions.

Source citation format

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first checked01 Aug 2026

judged → SUPPORTED · 8401 Aug 2026

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