Cellular components have distinct and measurable lifespans at the molecular level.
Cellular components and molecular constituents possess distinct, measurable lifespans and turnover rates governed by protein degradation and synthesis kinetics.
The claim states that cellular components have distinct and measurable lifespans at the molecular level. Multiple retrieved papers explicitly measure protein degradation rates, turnover kinetics, and half-lives of cellular components at the single-cell and molecular levels (e.g., Papers 1, 2, 3, and 11). Therefore, the claim is well-supported by empirical evidence.
Ming Yang, Benjamin R. Harrison, Daniel E. L. Promislow. Cellular age explains variation in age-related cell-to-cell transcriptome variability. 2023. https://doi.org/10.1101/gr.278144.123
Demonstrates that cellular components and cell types exhibit distinct turnover rates and lifespans that dictate biological aging.
See more details
Christian H. Gabriel, M. del Olmo, Arunya Rizki Widini, Rashin Roshanbin, Jonas Woyde, E. Hamza, Nica Gutu, A. Zehtabian, H. Ewers, Adrián E. Granada, H. Herzel, Achim Kramer. Circadian period is compensated for repressor protein turnover rates in single cells. 2024. https://doi.org/10.1073/pnas.2404738121
Shows that single-cell protein stability and repressor turnover rates vary and can be quantitatively measured.
David Vuković, Dorothea Winkelvoß, Jonas N. Kapp, Anna-Carina Hänny, Héloïse Bürgisser, Luca Riermeier, Anto Udovcic, Peter Tiefenboeck, Andreas Plückthun. Protein degradation kinetics measured by microinjection and live-cell fluorescence microscopy. 2024. https://doi.org/10.1038/s41598-024-76224-0
Measures distinct absolute degradation rates and half-lives for various proteins and cellular analytes at the single-cell level.
Daniel F. Bogenhagen. Selective over-synthesis and rapid turnover of mitochondrial protein components of respiratory complexes. 2019. https://doi.org/10.1101/832287
Finds distinct turnover and assembly kinetics, including rapid degradation of unassembled mitochondrial subunits, showing differential lifespans among molecular components.
The paper trail · every fact has a biography
Challenge the receipt
Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.
Terms · Privacy · How verdicts work · Dispute this receipt