Problematic memories can be selectively erased or modified

Ciobanu AC, Caseiro DM, Niu R, Triana Del Rio R, Leroux C, Stefanelli A, Nakandakare CF, Pralong E, Daniel RT, Lütjens R, van den Burg EH, Stoop R. Negative allosteric modulation of mGlu7 disrupts fear memory reconsolidation and glutamatergic signaling in rat and human brain tissue.. 2026. https://doi.org/10.1038/s41380-025-03202-x

Demonstrates that disrupting fear memory reconsolidation via mGlu7 modulation modifies memory persistence.

Bruce Ecker. Reconsolidation behavioral updating of human emotional memory: A comprehensive review and unified analysis of successes, replication failures, and clinical translation. 2021. https://doi.org/10.31234/osf.io/atz3m

Analyzes laboratory studies showing the modification and behavioral updating of human emotional memories via reconsolidation.

Xu R, Shi D, Wang K, Yang Q, Cao P, Wang Z. Progress in spatiotemporal regulation of fear memory: neural circuit mechanisms and implications for PTSD.. 2025. https://doi.org/10.1136/gpsych-2025-102224

Examines the spatiotemporal regulation of neural circuits underlying fear memory processes and modification.

Hiraoka S, Kumagai S, Yamasaki T. Empathy-Mediated Narrative Reconstruction of Autobiographical Memory: An Integrative Review of Theory, Evidence, and Applications.. 2026. https://doi.org/10.3390/brainsci16040429

Proposes an integrative model linking memory reconsolidation and narrative construction to update autobiographical memory.

Agnihotri R. The Neuroscience of Forgetting, Reconsolidation, and the Conceptual Architecture of a Targeted Memory Deletion System (TMDS). 2025. https://doi.org/10.20944/preprints202512.1288.v1

Outlines the conceptual architecture of targeted memory deletion systems by exploiting reconsolidation and destabilization windows.

Dietiker L, Zacher A, de'Sperati S, Loosli M, Schmid LB, Wernigg M, Rühlmann C, Bavato F, Zölch N, Seifritz E, Quednow BB, Kleim B. Attenuating trauma- and cocaine-related intrusions by blocking memory reconsolidation with minocycline: protocol for a transdiagnostic randomized controlled trial.. 2026. https://doi.org/10.1080/20008066.2026.2650920

Investigates pharmacological interference with reconsolidation to modulate trauma- and cocaine-related intrusive memories.

Bączek J, Karkosz S, Pietruch M, Szymański R, Michałowski JM. Imagine yourself as a little girl…-efficacy and psychophysiology of imagery techniques targeting adverse autobiographical childhood experiences- multi-arm randomised controlled trial.. 2025. https://doi.org/10.3389/fpsyg.2025.1710963

Shows that imagery rescripting techniques can successfully modify adverse autobiographical memories and emotional responses.

Colón LM, Famuyide OA, Eisch AJ. Dentate Gyrus Engrams in Fear and Reward: Mechanistic Principles, Critical Gaps, and Paths to Translation.. 2026. https://doi.org/10.1111/jnc.70413

Explores how memory reactivation opens a window for memory updates and reconsolidation.

Ni Y, Wang Y, Zhu Z, Hu J, Schiller D, Li J. Dissociable memory modulation mechanisms facilitate fear amnesia at different timescales.. 2025. https://doi.org/10.7554/elife.98652

Demonstrates that re-exposure protocols can re-evaluate and modify previously learned appetitive memories.

Warnecke C, Schweizer JA, Zattera B, Goldschmidt D, Leptien K, Felsenberg J. Re-exposure to reward re-evaluates related memories.. 2026. https://doi.org/10.1016/j.cub.2025.11.058

Suggests that specific therapeutic protocols facilitate memory reconsolidation to transform distressing memories.

Feinstein D. How tapping works: physiological and psychological mechanisms in energy psychology.. 2025. https://doi.org/10.3389/fpsyg.2025.1660375