Tuberculosis causes mortality through severe pulmonary damage
Is it true that tuberculosis causes mortality through severe pulmonary damage?
Yes. Tuberculosis causes mortality through severe pulmonary damage, supported by multiple studies documenting how Mycobacterium tuberculosis drives extensive tissue necrosis, extracellular matrix degradation, and cavitation.
Verdict: SUPPORTED · 5 sources for, 0 against · Last checked
The retrieved papers consistently support the claim that tuberculosis causes severe pulmonary damage and mortality through mechanisms such as ferroptosis-mediated necrosis, matrix metalloproteinase-driven extracellular matrix destruction, and caseous necrosis.
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Amaral, E. P., Costa, D. L., Namasivayam, S., Riteau, N., Kamenyeva, O., Mittereder, L. R., Mayer-Barber, K., Andrade, B., & Sher, A. (2019). A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis. doi.org. https://doi.org/10.1084/jem.20181776
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Amaral, E. P., Foreman, T. W., Namasivayam, S., Hilligan, K., Kauffman, K. D., Bomfim, C. C. B., Costa, D. L., Barreto-Duarte, B., Gurgel-Rocha, C., Santana, M. F., Cordeiro-Santos, M., Bruyn, E. d., Riou, C., Aberman, K., Wilkinson, R., Barber, D. L., Mayer-Barber, K., Andrade, B., & Sher, A. (2022). GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection. doi.org. https://doi.org/10.1084/jem.20220504
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Amaral, E. P., Namasivayam, S., Queiroz, A. T. L., Fukutani, E., Hilligan, K., Aberman, K., Fisher, L., Bomfim, C. C. B., Kauffman, K. D., Buchanan, J., Santuo, L., Gazzinelli-Guimarães, P., Costa, D. L., Teixeira, M. A., Barreto-Duarte, B., Rocha, C. A. G., Santana, M. F., Cordeiro-Santos, M., Barber, D. L., Wilkinson, R., Kramnik, I., Igarashi, K., Scriba, T., Mayer-Barber, K., Andrade, B. B., & Sher, A. (2023). BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility. doi.org. https://doi.org/10.1038/s41564-023-01523-7
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Shevchenko, O. S., Ovcharenko, I. A., & Todoriko, L. D. (2019). Pathophysiological Mechanisms Destruction of the Lung Connective Tissue in Tuberculosis. doi.org. https://doi.org/10.32902/2663-0338-2019-2-14-20
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MI, L., DLW, C., KH, S., & JS, F. (2026). Towards host-directed therapy: The role of matrix metalloproteinases in the immunopathogenesis of tuberculosis.. doi.org. https://doi.org/10.1016/j.ijid.2026.108525
What does the evidence say?
The retrieved papers consistently support the claim that tuberculosis causes severe pulmonary damage and mortality through mechanisms such as ferroptosis-mediated necrosis, matrix metalloproteinase-driven extracellular matrix destruction, and caseous necrosis.
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