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the claim

Tuberculosis causes mortality through severe pulmonary damage

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that tuberculosis causes mortality through severe pulmonary damage?

Yes. Tuberculosis causes mortality through severe pulmonary damage, supported by multiple studies documenting how Mycobacterium tuberculosis drives extensive tissue necrosis, extracellular matrix degradation, and cavitation.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked

The analysis

The retrieved papers consistently support the claim that tuberculosis causes severe pulmonary damage and mortality through mechanisms such as ferroptosis-mediated necrosis, matrix metalloproteinase-driven extracellular matrix destruction, and caseous necrosis.

Evidence for · 5
2019
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Amaral, E. P., Costa, D. L., Namasivayam, S., Riteau, N., Kamenyeva, O., Mittereder, L. R., Mayer-Barber, K., Andrade, B., & Sher, A. (2019). A major role for ferroptosis in Mycobacterium tuberculosis–induced cell death and tissue necrosis. doi.org. https://doi.org/10.1084/jem.20181776

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More for · 4
2022
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Amaral, E. P., Foreman, T. W., Namasivayam, S., Hilligan, K., Kauffman, K. D., Bomfim, C. C. B., Costa, D. L., Barreto-Duarte, B., Gurgel-Rocha, C., Santana, M. F., Cordeiro-Santos, M., Bruyn, E. d., Riou, C., Aberman, K., Wilkinson, R., Barber, D. L., Mayer-Barber, K., Andrade, B., & Sher, A. (2022). GPX4 regulates cellular necrosis and host resistance in Mycobacterium tuberculosis infection. doi.org. https://doi.org/10.1084/jem.20220504

2023
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Amaral, E. P., Namasivayam, S., Queiroz, A. T. L., Fukutani, E., Hilligan, K., Aberman, K., Fisher, L., Bomfim, C. C. B., Kauffman, K. D., Buchanan, J., Santuo, L., Gazzinelli-Guimarães, P., Costa, D. L., Teixeira, M. A., Barreto-Duarte, B., Rocha, C. A. G., Santana, M. F., Cordeiro-Santos, M., Barber, D. L., Wilkinson, R., Kramnik, I., Igarashi, K., Scriba, T., Mayer-Barber, K., Andrade, B. B., & Sher, A. (2023). BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility. doi.org. https://doi.org/10.1038/s41564-023-01523-7

2019
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Shevchenko, O. S., Ovcharenko, I. A., & Todoriko, L. D. (2019). Pathophysiological Mechanisms Destruction of the Lung Connective Tissue in Tuberculosis. doi.org. https://doi.org/10.32902/2663-0338-2019-2-14-20

2026
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MI, L., DLW, C., KH, S., & JS, F. (2026). Towards host-directed therapy: The role of matrix metalloproteinases in the immunopathogenesis of tuberculosis.. doi.org. https://doi.org/10.1016/j.ijid.2026.108525

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What does the evidence say?

The retrieved papers consistently support the claim that tuberculosis causes severe pulmonary damage and mortality through mechanisms such as ferroptosis-mediated necrosis, matrix metalloproteinase-driven extracellular matrix destruction, and caseous necrosis.

Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 9104 Aug 2026
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