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the claim

True Mendelian traits exist that do not display polygeny

the verdict
SUPPORTED
the evidence backs this
Recorded sources
7 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that true Mendelian traits exist that do not display polygeny?

Yes. Multiple genetic and clinical studies confirm the existence of true Mendelian traits that follow single-gene inheritance patterns without a polygenic basis, such as monogenic disorders and specific phenotypic traits like earwax type.

Verdict: SUPPORTED · 7 sources for, 0 against · Last checked

The analysis

The claim states that true Mendelian traits exist that do not display polygeny. Numerous papers in the literature discuss monogenic Mendelian disorders and single-gene traits (such as the ABCC11 earwax polymorphism or familial chylomicronemia syndrome) as distinct from complex polygenic traits. All relevant papers support the existence of monogenic Mendelian inheritance. Therefore, the verdict is SUPPORTED.

Evidence for · 7
Genome editing as a tool to achieve the crop ideotype and de novo domestication of wild relatives: Case study in tomato.
2017
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Zsögön, A., Čermák, T., Voytas, D., & Peres, L. (2017). Genome editing as a tool to achieve the crop ideotype and de novo domestication of wild relatives: Case study in tomato.. doi.org. https://doi.org/10.1016/j.plantsci.2016.12.012

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More for · 6
Precision Medicine in Internal Medicine
2019
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Kiryluk, K., Goldstein, D., Rowe, J., Gharavi, A., Wapner, R., & Chung, W. (2019). Precision Medicine in Internal Medicine. doi.org. https://doi.org/10.7326/M18-0425

Monogenic and polygenic concepts in chronic kidney disease (CKD)
2023
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Jefferis, J., Hudson, R., Lacaze, P., Bakshi, A., Hawley, C., Patel, C., & Mallett, A. (2023). Monogenic and polygenic concepts in chronic kidney disease (CKD). doi.org. https://doi.org/10.1007/s40620-023-01804-8

Equus in Online Mendelian Inheritance in Animals (OMIA)
2024
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Tammen, I., Bailey, E., Mather, M., & Nicholas, F. W. (2024). Equus in Online Mendelian Inheritance in Animals (OMIA). doi.org. https://doi.org/10.3390/ani14142069

Familial Chylomicronemia Syndrome With a Novel Homozygous LPL Mutation Identified in Three Siblings in Their 50s
2019
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Ueda, M., Burke, F. M., Remaley, A., Hegele, R., Rader, D., & Dunbar, R. L. (2019). Familial Chylomicronemia Syndrome With a Novel Homozygous LPL Mutation Identified in Three Siblings in Their 50s. doi.org. https://doi.org/10.7326/L19-0568

Genome-wide association studies, Polygenic Risk Scores and Mendelian randomisation: an overview of common genetic epidemiology methods for ophthalmic clinicians.
2025
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SS, L., F, S., S, M., & DA, M. (2025). Genome-wide association studies, Polygenic Risk Scores and Mendelian randomisation: an overview of common genetic epidemiology methods for ophthalmic clinicians.. doi.org. https://doi.org/10.1136/bjo-2024-326554

ABCC11 Earwax Trait and Genotype Are Suitable Tools for Introductory Labs to Learn Genetics and Molecular Techniques.
2025
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T, O., R, T., A, Y., D, P., S, G., T, K., T, A., Y, K., & T, T. (2025). ABCC11 Earwax Trait and Genotype Are Suitable Tools for Introductory Labs to Learn Genetics and Molecular Techniques.. doi.org. https://doi.org/10.1002/bmb.70010

What does the evidence say?

The claim states that true Mendelian traits exist that do not display polygeny. Numerous papers in the literature discuss monogenic Mendelian disorders and single-gene traits (such as the ABCC11 earwax polymorphism or familial chylomicronemia syndrome) as distinct from complex polygenic traits. All relevant papers support the existence of monogenic Mendelian inheritance. Therefore, the verdict is SUPPORTED.

Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 8804 Aug 2026
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