Transcription factors bind to both strands of DNA

the verdict

SUPPORTED

the evidence backs this

Recorded sources

2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that transcription factors bind to both strands of DNA?

Yes. Evidence shows that transcription factors can make strand-specific contacts and even bridge across multiple DNA strands.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked 31 Jul 2026

The analysis

The retrieved literature includes studies showing transcription factor sensitivity to strand-specific contexts (such as hemimethylation) and multi-strand interactions like DNA bridging by multimeric transcription factors, thereby supporting the claim.

Evidence for · 2

DNA methylation shapes transcription factor binding beyond canonical CpG contexts.

2025

Get citation

Miodownik, I., Solozabal, R., O'Hagan, M. P., Albeck, S., Peleg, Y., Takac, M., & Afek, A. (2025). DNA methylation shapes transcription factor binding beyond canonical CpG contexts.. doi.org. https://doi.org/10.1073/pnas.2520814122

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More for · 1

FOXP3 recognizes microsatellites and bridges DNA through multimerization.

2023

Get citation

Zhang, W., Leng, F., Wang, X., Ramirez, R. N., Park, J., Benoist, C., & Hur, S. (2023). FOXP3 recognizes microsatellites and bridges DNA through multimerization.. doi.org. https://doi.org/10.1038/s41586-023-06793-z

Related receipts

Is it true that the human genome encodes a specific number of transcription factors? SUPPORTED related question, same topic
Is it true that DNA replication requires RNA primers while transcription does not? SUPPORTED related question, same topic
Is it true that Nucleosomes completely unwrap from DNA during active transcription? REFUTED related question, same topic
Is it true that methylation from DNA gets copied to RNA during transcription? REFUTED related question, same topic
Is it true that the terms 5 prime and 3 prime designate the directional orientation of DNA and RNA strands? COMMON KNOWLEDGE related question, same topic
Is it true that specific DNA sequence characteristics influence the transcription efficiency of T7 RNA polymerase? SUPPORTED related question, same topic

What does the evidence say?

Receipt History

first checked31 Jul 2026

judged → SUPPORTED · 7531 Jul 2026

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