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the claim
Topologically associating domains are structural units of genome folding
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SUPPORTED
the evidence backs this
Recorded sources
14 sources for · 1 against
Is it true that Topologically associating domains are structural units of genome folding?
Yes. Multiple peer-reviewed studies and authoritative references consistently establish that topologically associating domains (TADs) are structural and organizational units of three-dimensional genome folding.
Verdict: SUPPORTED · 14 sources for, 1 against · Last checked
How claims like this are judged
Judged against reference works: claims of this kind are settled by reference works, not journal abstracts.
Evidence for · 14
Reference article covering this claim directly
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Wikipedia: Topologically associating domain. (n.d.). Wikipedia. https://en.wikipedia.org/wiki/Topologically_associating_domain
Evidence against · 1
Notes that TADs depend on cohesin and are regulated by CTCF.
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ebi.ac.uk: Topologically associating domains and chromatin loops depend on cohesin and are regulated by CTCF, WAPL, and PDS5 proteins. — instance of. (n.d.). ebi.ac.uk. https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29217591%20AND%20SRC:MED&resulttype=core&format=json
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More for · 13
Discusses DNA loops as basic units of genome organization.
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Academic Press: Nuclear matrix : structural and functional organization. (1995). Academic Press. https://archive.org/details/nuclearmatrixstr0000unse
States that eukaryotic genomes are organized into structural units called topologically associating domains.
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Yan, K., Lou, S., & Gerstein, M. (2017). PLoS Computational Biology: MrTADFinder: A network modularity based approach to identify topologically associating domains in multiple resolutions.. PLoS Computational Biology. https://doi.org/10.1371/journal.pcbi.1005647
Explicitly states that TADs are the structural units of chromatin and 3D genome organization.
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Kumar, S., Kaur, S., Seem, K., Kumar, S., & Mohapatra, T. (2021). Frontiers in Cell and Developmental Biology: Understanding 3D Genome Organization and Its Effect on Transcriptional Gene Regulation Under Environmental Stress in Plant: A Chromatin Perspective. Frontiers in Cell and Developmental Biology. https://doi.org/10.3389/fcell.2021.774719
Describes mammalian genomes partitioned into TADs functioning as structural scaffolds.
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Willemin, A., Lopez-Delisle, L., Bolt, C. C., Gadolini, M., Duboule, D., & Rodriguez-Carballo, E. (2021). PLoS Genetics: Induction of a chromatin boundary in vivo upon insertion of a TAD border.. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1009691
Identifies TADs as critical structural units in three-dimensional genome organization.
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Hua, D., Gu, M., Zhang, X., Du, Y., Xie, H., & Qi, L. (2024). Nature Communications: DiffDomain enables identification of structurally reorganized topologically associating domains. Nature Communications. https://doi.org/10.1038/s41467-024-44782-6
References TADs as domains within which regulatory interactions occur.
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An, L., Yang, T., Yang, J., Nuebler, J., Xiang, G., & Hardison, R. C. (2019). Genome Biology: OnTAD: hierarchical domain structure reveals the divergence of activity among TADs and boundaries. Genome Biology. https://doi.org/10.1186/s13059-019-1893-y
Lists TADs as multiscale structural units of the eukaryotic genome.
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Cheng, J., Cao, X., Wang, S., Zhang, J., Yue, B., & Zhang, X. (2024). Journal of Integrative Agriculture: 3D genome organization and its study in livestock breeding. Journal of Integrative Agriculture. https://doi.org/10.1016/j.jia.2023.04.007
OpenAIRE: Measuring the three-dimensional structural properties of topologically associating domains
Notes TADs are genomic regions that serve as structural and functional units.
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OpenAIRE: Measuring the three-dimensional structural properties of topologically associating domains. (2018). OpenAIRE. https://doi.org/10.1109/bibm.2018.8621459
Describes TADs as essential components of 3D genome organization.
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OpenAIRE: Uncovering topologically associating domains from three-dimensional genome maps with TADGATE. (2024). OpenAIRE. https://doi.org/10.1093/nar/gkae1267
States TADs are organizational units of chromosome structures.
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OpenAIRE: SuperTAD: robust detection of hierarchical topologically associated domains with optimized structural information. (2021). OpenAIRE. https://doi.org/10.1186/s13059-020-02234-6
Discusses TADs as conserved domains within chromatin architecture.
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OpenAIRE: Topologically associating domains are stable units of replication-timing regulation. (2014). OpenAIRE. https://doi.org/10.1038/nature13986
Describes TADs as fundamental units of three-dimensional eukaryotic genomic organization.
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OpenAIRE: Topologically associating domains and their role in the evolution of genome structure and function in Drosophila. (2020). OpenAIRE. https://doi.org/10.1101/2020.05.13.094516
States TADs are structural units of 3D genome organization.
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OpenAIRE: TADs: Dynamic structures to create stable regulatory functions. (2023). OpenAIRE. https://doi.org/10.1016/j.sbi.2023.102622
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first checked06 Aug 2026
judged → SUPPORTED · 5806 Aug 2026
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