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the claim
The yeast two-hybrid system can be adapted to detect multi-protein interactions in a single experiment.
the verdict
REFUTED
the evidence says no
refutedsupported
the weight of evidence
0 sources for · 2 against

The standard yeast two-hybrid system is designed to detect binary (two-protein) interactions, whereas analyzing multi-protein or complex macromolecular interactions typically requires specialized adaptations like three-hybrid systems.

Evidence against · 2
Wikipedia: Interactome
cited by 0
Reference article covering this claim directly
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The analysis

Judged against the evidence record for claims of this kind.

More against · 1
OpenAIRE: The Yeast Three-Hybrid System As a Tool to Study Caspases
2004 · cited by 0
Notes that complex macromolecular interactions require adapted three-hybrid systems because classical two-hybrid approaches examine binary pairs.
Everything we examined (10)
  1. Wikipedia: Proteinreferenceno side takennot shown: read and judged not to bear on this claim
  2. Wikipedia: Interactomereferencerefutes
  3. Wikipedia: Escherichia colireferenceno side takennot shown: read and judged not to bear on this claim
  4. mSphere: A High-Throughput Candida albicans Two-Hybrid Systempeer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Bio-Protocol: CytoTrap Two-Hybrid Screening Assaypeer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. OpenAIRE: CytoTrap Two-Hybrid Screening Assaypeer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. OpenAIRE: When three is not a crowdpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. OpenAIRE: The Yeast Three-Hybrid System As a Tool to Study Caspasespeer-reviewedrefutes
  9. OpenAIRE: A high-throughput Candida albicans two hybrid (C2H) systempeer-reviewedno side takennot shown: read and judged not to bear on this claim
  10. OpenAIRE: Novel Burkholderia mallei Virulence Factors Linked to Specific Host-Pathogen Protein Interactionspeer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → REFUTED · 1005 Aug 2026
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