The synaptic cleft is maintained through specific structural cell adhesion molecules
Is it true that the synaptic cleft is maintained through specific structural cell adhesion molecules?
Yes. The synaptic cleft and the structural integrity between pre- and postsynaptic terminals are maintained through specific trans-synaptic cell adhesion molecules.
Verdict: SUPPORTED · 6 sources for, 0 against · Last checked
The retrieved literature consistently supports the claim that synaptic adhesion molecules (such as neurexins, LRR-containing proteins, and dystroglycan) are responsible for establishing, bridging, and maintaining the structural architecture of the synaptic cleft. Multiple papers detail how these specific molecular interactions link pre- and postsynaptic compartments. Therefore, the verdict is SUPPORTED.
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Oliver, D., Ramachandran, S., Philbrook, A., Lambert, C. M., Nguyen, K., Hall, D., & Francis, M. (2022). Kinesin-3 mediated axonal delivery of presynaptic neurexin stabilizes dendritic spines and postsynaptic components. doi.org. https://doi.org/10.1371/journal.pgen.1010016
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Han, K. A., Um, J., & Ko, J. (2019). Intracellular protein complexes involved in synapse assembly in presynaptic neurons.. doi.org. https://doi.org/10.1016/BS.APCSB.2018.11.008
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Yamagata, A. & Fukai, S. (2019). Structural insights into leucine-rich repeat-containing synaptic cleft molecules.. doi.org. https://doi.org/10.1016/j.sbi.2019.01.001
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Liao, L., Han, Y., Niu, F., Wang, Y., Lu, Y., Xu, S., Zhu, H., Lin, L., Xiao, J., Tou, H. I., Gao, J., Zhang, B., & Wei, Z. (2025). Structural basis of calcium-dependent C1ql1/BAI3 assemblies in synaptic connectivity. doi.org. https://doi.org/10.1038/s41467-025-66254-1
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Jahncke, J. N., Schnell, E., & Wright, K. M. (2025). Distinct functional domains of Dystroglycan regulate inhibitory synapse formation and maintenance in cerebellar Purkinje cells. doi.org. https://doi.org/10.1038/s42003-025-08323-1
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J, L., YI, K., M, U., & K, F. (2026). Roles of synaptic cell adhesion molecules in the neuromodulatory systems.. doi.org. https://doi.org/10.1016/j.mocell.2026.100340
What does the evidence say?
The retrieved literature consistently supports the claim that synaptic adhesion molecules (such as neurexins, LRR-containing proteins, and dystroglycan) are responsible for establishing, bridging, and maintaining the structural architecture of the synaptic cleft. Multiple papers detail how these specific molecular interactions link pre- and postsynaptic compartments. Therefore, the verdict is SUPPORTED.
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