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the claim
The reaction of a primary amine with an acid anhydride yields an amide
the verdict
COMMON KNOWLEDGE
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the weight of evidence
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The reaction between a primary amine and an acid anhydride to form an amide is a fundamental, textbook reaction in organic chemistry and does not require citation.

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The analysis

The claim states a basic chemical fact taught in introductory organic chemistry: primary amines react with acid anhydrides via nucleophilic acyl substitution to yield amides. Because this is a standard definition and everyday observation in chemical synthesis, it is classified as common knowledge.

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first checked04 Aug 2026
judged → COMMON KNOWLEDGE · 9504 Aug 2026
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