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the claim
The human genome contains genes inherited from the universal common ancestor
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
6 sources for · 0 against

Modern biochemistry and comparative genomics strongly support the conclusion that all extant cellular life shares genes inherited from the last universal common ancestor (LUCA).

Evidence for · 6
The nature of the last universal common ancestor and its impact on the early Earth system
2024 · cited by 189
The paper reconstructs LUCA's genome and protein inventory, indicating significant genetic inheritance from the last universal common ancestor.
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The analysis

The retrieved papers consistently demonstrate that genomic and phylogenetic analyses identify numerous gene families, protein domains, and universal paralogs inherited from the Last Universal Common Ancestor (LUCA). There is no evidence in the retrieved set disputing the existence of genes inherited from LUCA.

More for · 5
Order of amino acid recruitment into the genetic code resolved by last universal common ancestor’s protein domains
2024 · cited by 30
The study identifies protein domains dating back to LUCA to trace amino acid recruitment into the genetic code.
Glutamine synthetase evolutionary history revisited: Tracing back beyond the Last Universal Common Ancestor
2022 · cited by 20
The research evaluates glutamine synthetase gene families tracing back beyond the Last Universal Common Ancestor.
The Unfinished Reconstructed Nature of the Last Universal Common Ancestor
2024 · cited by 6
The review discusses how molecular biology and shared ancestry trace genes and protein subunits back to LUCA.
Phenotypic reconstruction of the last universal common ancestor reveals a complex cell
2020 · cited by 4
The study reconstructs LUCA's complex cellular phenotype and genome based on phylogenetically informed ancestral character reconstruction.
Universal paralogs provide a window into evolution before the last universal common ancestor.
2026 · cited by 2
The paper highlights universal paralogs that retain phylogenetic signals and gene history from evolutionary events predating LUCA.
Everything we examined (12)
We also searched for evidence AGAINST this claim, not only for it.
  1. The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transferspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  2. The nature of the last universal common ancestor and its impact on the early Earth systempeer-reviewedsupports
  3. Order of amino acid recruitment into the genetic code resolved by last universal common ancestor’s protein domainspeer-reviewedsupports
  4. Glutamine synthetase evolutionary history revisited: Tracing back beyond the Last Universal Common Ancestorpeer-reviewedsupports
  5. The Unfinished Reconstructed Nature of the Last Universal Common Ancestorpeer-reviewedsupports
  6. Positively twisted: The complex evolutionary history of Reverse Gyrase suggests a non-hyperthermophilic Last Universal Common Ancestorpeer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Looking for the Last Universal Common Ancestor (LUCA)peer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. Phenotypic reconstruction of the last universal common ancestor reveals a complex cellpeer-reviewedsupports
  9. Universal paralogs provide a window into evolution before the last universal common ancestor.peer-reviewedsupports
  10. DPANN Archaea and CPR Bacteria: insights into early cellular evolution?peer-reviewedno side takennot shown: read and judged not to bear on this claim
  11. Be Introduced to the First Universal Common Ancestor (FUCA): The Great-Grandmother of LUCA (Last Universal Common Ancestor)peer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. Phyling: phylogenetic inference from annotated genomes.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked06 Aug 2026
judged → SUPPORTED · 8906 Aug 2026
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