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the claim
Specific physiological factors cause aortic aneurysms
the verdict
SUPPORTED
the evidence backs this
Recorded sources
12 sources for · 0 against
Is it true that specific physiological factors cause aortic aneurysms?
Yes. Extensive scientific evidence establishes that specific physiological factors—including inflammation, extracellular matrix degradation, smooth muscle cell dysfunction, and genetic pathways—drive the development and progression of aortic aneurysms.
Verdict: SUPPORTED · 12 sources for, 0 against · Last checked
The analysis
The retrieved papers consistently document the molecular, cellular, and physiological mechanisms (such as inflammation, ECM degradation, and VSMC switching) that cause aortic aneurysms. All relevant papers support the claim, leading to a verdict of SUPPORTED.
Evidence for · 12
Identifies multiple physiological mechanisms, including inflammation and protein degradation, that cause aortic aneurysms.
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Domagała, D., Data, K., Szyller, H., Farzaneh, M., Mozdziak, P., Woźniak, S., Zabel, M., Dzięgiel, P., & Kempisty, B. (2024). Cellular, Molecular and Clinical Aspects of Aortic Aneurysm—Vascular Physiology and Pathophysiology. doi.org. https://doi.org/10.3390/cells13030274
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More for · 11
Shows that extracellular matrix degradation driven by specific molecular axes contributes to abdominal aortic aneurysm pathogenesis.
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Wang, S., Yuan, Q., Zhao, W., & Zhou, W. (2021). Circular RNA RBM33 contributes to extracellular matrix degradation <i>via</i> miR-4268/EPHB2 axis in abdominal aortic aneurysm. doi.org. https://doi.org/10.7717/peerj.12232
Highlights the central role of physiological processes like vascular inflammation and smooth muscle cell dysfunction in aneurysm pathogenesis.
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II, S., S, S., Y, F., KA, S., J, W., Q, Z., S, W., C, Z., & C, S. (2025). Therapeutic Targeting of Signaling Pathways in Abdominal Aortic Aneurysm: From Pathogenesis to Precision Medicine.. doi.org. https://doi.org/10.2147/dddt.s563581
Examines molecular mechanisms such as smooth muscle cell apoptosis, chronic inflammation, and oxidative stress in aortic aneurysms.
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Ardahanlı, I., Aslan, R., Özkan, H., Özel, F., & Özmen, M. (2025). A Contemporary Review of Thoracic Aortic Aneurysm: From Molecular Pathogenesis to Clinical Integration. doi.org. https://doi.org/10.3390/jvd4030026
Demonstrates that cellular heterogeneity, smooth muscle cell phenotypic transitions, and endothelial dysfunction drive aortic aneurysm progression.
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Song, T., Han, Y., Xie, L., & Ji, Y. (2026). Cellular Heterogeneity in Aortic Aneurysm and Dissection: Molecular Mechanisms and Therapeutic Opportunities.. doi.org. https://doi.org/10.1161/circresaha.125.327197
Provides evidence that immune cell infiltration and neutrophil-driven processes are critical to abdominal aortic aneurysm pathogenesis.
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Yang, B., Xu, Y., Yan, F., Peng, C., Song, Y., Han, S., & Wang, H. (2025). Identifying nexilin as a central gene in neutrophil-driven abdominal aortic aneurysm pathogenesis. doi.org. https://doi.org/10.1186/s10020-025-01157-x
Details core genetic and molecular mechanisms, including extracellular matrix disruption and vascular smooth muscle cell dysfunction, in hereditary thoracic aortic aneurysms.
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X, W., Q, T., J, X., Y, Y., H, H., X, T., & W, W. (2026). Genetic and molecular mechanisms of hereditary thoracic aortic aneurysm and dissection (Review).. doi.org. https://doi.org/10.3892/mmr.2026.13942
Explains that aortic aneurysms are driven by biological mechanisms such as extracellular matrix remodeling and inflammatory responses.
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B, H. & W, Y. (2026). Pathogenesis, Diagnosis, and Clinical Management of Aortic Aneurysms: Current Status and Future Perspectives.. doi.org. https://doi.org/10.31083/rcm49246
Links alternative splicing and cellular aging mechanisms in vascular smooth muscle cells to abdominal aortic aneurysm formation.
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Y, L., K, T., S, L., Y, W., Q, C., S, W., X, Z., X, W., H, L., X, L., W, W., L, Z., L, Z., J, S., J, L., Y, Z., J, W., & B, Z. (2026). RNA helicase MTR4 aggravates abdominal aortic aneurysm formation by recruiting SRSF1 to regulate TERT alternative splicing.. doi.org. https://doi.org/10.1016/j.bbadis.2026.168374
Identifies causal genes and immune dysregulation pathways linked to the physiological risk of abdominal aortic aneurysm.
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Y, Z., J, R., L, Z., Y, Y., R, D., & L, Z. (2026). Single-cell sequencing combined with Mendelian randomization to explore the molecular mechanisms related to abdominal aortic aneurysm. doi.org. https://doi.org/10.21203/rs.3.rs-9531234/v1
Demonstrates that epigenetic regulation and autophagy in vascular smooth muscle cells play direct roles in the development of thoracic aortic aneurysm and dissection.
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Y, B., Y, Z., Y, N., Y, H., D, L., R, X., & X, F. (2026). DNMT3B attenuates the development of thoracic aortic aneurysm and dissection by suppressing TFEB-mediated autophagy in vascular smooth muscle cells.. doi.org. https://doi.org/10.1016/j.bbadis.2026.168331
Shows that inflammatory factors, metalloproteinase-mediated degradation, and immune cell infiltration are key pathological drivers of aortic aneurysms.
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F, Z., Y, L., D, Z., & J, G. (2026). Targeting IL-1β: a potential strategy for alleviating the immunopathology of aortic aneurysms.. doi.org. https://doi.org/10.3389/fimmu.2026.1821082
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What does the evidence say?
The retrieved papers consistently document the molecular, cellular, and physiological mechanisms (such as inflammation, ECM degradation, and VSMC switching) that cause aortic aneurysms. All relevant papers support the claim, leading to a verdict of SUPPORTED.
Receipt History
first checked06 Aug 2026
judged → SUPPORTED · 8406 Aug 2026
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