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the claim

Single-stranded RNA binds to double-stranded DNA via Hoogsteen base pairing to form triplex structures

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that single-stranded RNA binds to double-stranded DNA via Hoogsteen base pairing to form triplex structures?

Yes. Single-stranded RNA can bind to double-stranded DNA via Hoogsteen base pairing to form triplex structures, a mechanism supported by literature on non-canonical nucleic acid interactions and DNA-RNA triplex predictions.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

The analysis

The retrieved papers, particularly references [7] and [9], directly state that single-stranded nucleic acid or RNA molecules interact via Hoogsteen bonds with DNA double helices to form triplex structures (DNA-RNA triple helices). Therefore, the claim is supported by the literature.

Evidence for · 2
Identifying triplex binding rules in vitro leads to creation of a new synthetic regulatory tool in vivo
2019
The study discusses nucleic acid structures where a single-stranded nucleic acid molecule interacts via Hoogsteen bonds with a double helix.
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Kaufmann, B., Willinger, O., Eden, N., Kermas, L., Anavy, L., Solomon, O., Atar, O., Yakhini, Z., Goldberg, S., & Amit, R. (2019). Identifying triplex binding rules in vitro leads to creation of a new synthetic regulatory tool in vivo. doi.org. https://doi.org/10.1101/2019.12.25.888362

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More for · 1
Easy triplex: An online tool for predicting the formation of DNA-RNA triple helices.
2025
The paper notes that intranuclear noncoding RNAs form DNA-RNA triple helices through the base pairing of target sites and oligonucleotides using canonical Hoogsteen rules.
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L, X., J, L., S, Z., F, L., H, L., L, Z., M, S., C, G., Z, L., & T, G. (2025). Easy triplex: An online tool for predicting the formation of DNA-RNA triple helices.. doi.org. https://doi.org/10.1016/j.csbj.2025.04.008

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What does the evidence say?

The retrieved papers, particularly references [7] and [9], directly state that single-stranded nucleic acid or RNA molecules interact via Hoogsteen bonds with DNA double helices to form triplex structures (DNA-RNA triple helices). Therefore, the claim is supported by the literature.

Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 7804 Aug 2026
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