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the claim

RNA primers serve a specific function in DNA replication

the verdict

SUPPORTED

the evidence backs this

Recorded sources

5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that RNA primers serve a specific function in DNA replication?

Yes. RNA primers are essential for DNA replication, as primase enzymes synthesize short RNA sequences that provide the free 3'-OH group required by DNA polymerases to begin DNA strand elongation.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked 1 Aug 2026

The analysis

The claim is specific, empirical, and contestable (it makes a precise biochemical statement about the role of RNA primers in DNA replication). Retrieved papers 0 through 4 provide extensive biochemical evidence across multiple organisms (mammals, yeast, humans, and viruses) showing that primases synthesize RNA primers to initiate DNA replication. Thus, the claim is clearly supported by the evidence.

Evidence for · 5

Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication.

1993

Demonstrates that mammalian primase subunits initiate DNA replication by extending or synthesizing RNA primers.

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Copeland, W. C. & Wang, T. S. (1993). Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication.. doi.org. https://doi.org/10.1016/s0021-9258(19)74297-5

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More for · 4

Isolation and characterization of a DNA primase from human mitochondria.

1985

Shows that human mitochondrial primase synthesizes RNA primers that are covalently linked to nascent DNA during replication initiation.

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Wong, T. & Clayton, D. (1985). Isolation and characterization of a DNA primase from human mitochondria.. doi.org. https://doi.org/10.1016/s0021-9258(17)39063-4

A DNA primase from mouse cells. Purification and partial characterization.

1983

Purifies a mouse DNA primase that synthesizes oligoribonucleotides serving as primers to initiate DNA synthesis.

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Tseng, B. & Ahlem, C. (1983). A DNA primase from mouse cells. Purification and partial characterization.. doi.org. https://doi.org/10.1016/s0021-9258(17)44575-3

Structural Basis for the Interaction of a Hexameric Replicative Helicase with the Regulatory Subunit of Human DNA Polymerase α-Primase*

2012

Notes that the eukaryotic DNA polymerase alpha-primase complex plays an essential role by initiating synthesis of the leading strand and Okazaki fragments with an RNA primer.

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Zhou, B., Arnett, D. R., Yu, X., Brewster, A., Sowd, G. A., Xie, C., Vila, S., Gai, D., Fanning, E., & Chen, X. S. (2012). Structural Basis for the Interaction of a Hexameric Replicative Helicase with the Regulatory Subunit of Human DNA Polymerase α-Primase*. doi.org. https://doi.org/10.1074/jbc.M112.363655

DNA primase isolated from the yeast DNA primase-DNA polymerase complex. Immunoaffinity purification and analysis of RNA primer synthesis.

1989

Finds that yeast DNA primase is an RNA-polymerizing enzyme that specifically synthesizes RNA oligomers to function as primers in replication.

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Brooks, M. & Dumas, L. B. (1989). DNA primase isolated from the yeast DNA primase-DNA polymerase complex. Immunoaffinity purification and analysis of RNA primer synthesis.. doi.org. https://doi.org/10.1016/s0021-9258(18)94109-8

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Receipt History

first checked01 Aug 2026

judged → SUPPORTED · 8801 Aug 2026

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