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the claim

RNA polymerase predictably fails to transcribe repetitive sequences accurately

the verdict
SUPPORTED
the evidence backs this
Recorded sources
6 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that RNA polymerase predictably fails to transcribe repetitive sequences accurately?

Yes. Multiple studies demonstrate that RNA polymerases predictably undergo transcriptional slippage or inaccurate synthesis when encountering repetitive sequences and homopolymeric stretches.

Verdict: SUPPORTED · 6 sources for, 0 against · Last checked

The analysis

The retrieved papers consistently report that RNA polymerases across various organisms and viruses predictably experience transcriptional slippage (indels) when transcribing repetitive sequences and homopolymeric runs. No papers refute this phenomenon; instead, they detail its mechanisms, predictability, and biological consequences. Therefore, the verdict is SUPPORTED.

Evidence for · 6
Transcriptional slippage in the positive-sense RNA virus family Potyviridae
2015
Demonstrates that viral RNA polymerases predictably undergo transcriptional slippage when encountering conserved repetitive sequences like GAAAAAA.
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Olspert, A., Chung, B., Atkins, J. F., Carr, J., & Firth, A. (2015). Transcriptional slippage in the positive-sense RNA virus family Potyviridae. doi.org. https://doi.org/10.15252/embr.201540509

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More for · 5
Massively Systematic Transcript End Readout (MASTER): Transcription Start Site Selection, Transcriptional Slippage, and Transcript Yields
2015
Shows via high-throughput sequencing that reiterative initiation and transcriptional slippage occur predictably from the majority of transcription start site region sequences.
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Vvedenskaya, I., Zhang, Y., Goldman, S. R., Valenti, A., Visone, V., Taylor, D. M., Ebright, R., & Nickels, B. E. (2015). Massively Systematic Transcript End Readout (MASTER): Transcription Start Site Selection, Transcriptional Slippage, and Transcript Yields. doi.org. https://doi.org/10.1016/j.molcel.2015.10.029

Truncated yet functional viral protein produced via RNA polymerase slippage implies underestimated coding capacity of RNA viruses
2016
Indicates that viral RNA-dependent RNA polymerases predictably slip at conserved homopolymeric motifs to produce alternative reading frame proteins.
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Hagiwara-Komoda, Y., Choi, S., Sato, M., Atsumi, G., Abe, J., Fukuda, J., Honjo, M., Nagano, A., Komoda, K., Nakahara, K., Uyeda, I., & Naito, S. (2016). Truncated yet functional viral protein produced via RNA polymerase slippage implies underestimated coding capacity of RNA viruses. doi.org. https://doi.org/10.1038/srep21411

Non-programmed transcriptional frameshifting is common and highly RNA polymerase type-dependent
2018
Compares RNA polymerases and confirms that they predictably exhibit propensity for non-programmed transcriptional slippage at homopolymeric sequences in a sequence-dependent manner.
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Koscielniak, D., Wons, E., Wilkowska, K., & Sektas, M. (2018). Non-programmed transcriptional frameshifting is common and highly RNA polymerase type-dependent. doi.org. https://doi.org/10.1186/s12934-018-1034-4

Propensity of a picornavirus polymerase to slip on potyvirus-derived transcriptional slippage sites
2018
Finds that viral polymerases predictably slip at specific homopolymeric nucleotide runs during RNA synthesis.
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Stewart, H., Olspert, A., Butt, B. G., & Firth, A. (2018). Propensity of a picornavirus polymerase to slip on potyvirus-derived transcriptional slippage sites. doi.org. https://doi.org/10.1099/jgv.0.001189

Reconceptualizing transcriptional slippage in plant RNA viruses
2024
Highlights that transcriptional slippage by viral replicases consistently occurs when transcribing specific repetitive motifs such as An stretches.
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Valli, A. A., Domingo-Calap, M. L., Prádena, A. G. d., García, J. A., Cui, H., Desbiez, C., & López-Moya, J. (2024). Reconceptualizing transcriptional slippage in plant RNA viruses. doi.org. https://doi.org/10.1128/mbio.02120-24

What does the evidence say?

The retrieved papers consistently report that RNA polymerases across various organisms and viruses predictably experience transcriptional slippage (indels) when transcribing repetitive sequences and homopolymeric runs. No papers refute this phenomenon; instead, they detail its mechanisms, predictability, and biological consequences. Therefore, the verdict is SUPPORTED.

Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 8904 Aug 2026
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