Replication protein complexes and checkpoint signaling regulate the timing of DNA replication
Is it true that replication protein complexes and checkpoint signaling regulate the timing of DNA replication?
Yes. Multiple studies demonstrate that replication protein complexes and checkpoint signaling pathways work together to control the timing and execution of DNA replication origin firing.
Verdict: SUPPORTED · 5 sources for, 0 against · Last checked
The retrieved papers consistently show that checkpoint kinases (such as Chk1) and pre-replication complexes regulate DNA replication timing and origin firing. The evidence heavily supports the claim, with no papers offering refutation.
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Feijóo, C., Hall-Jackson, C., Wu, R., Jenkins, D. M., Leitch, J., Gilbert, D., & Smythe, C. (2001). Activation of mammalian Chk1 during DNA replication arrest. doi.org. https://doi.org/10.1083/jcb.200104099
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Mattarocci, S., Shyian, M., Lemmens, L., Damay, P., Altintas, D., Shi, T., Bartholomew, C. R., Thomä, N., Hardy, C. F., & Shore, D. (2014). Rif1 controls DNA replication timing in yeast through the PP1 phosphatase Glc7.. doi.org. https://doi.org/10.1016/j.celrep.2014.03.010
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Ferreira, P., Höfer, V., Kronshage, N., Marko, A., Reusswig, K., Tetik, B., Dießel, C., Köhler, K., Tschernoster, N., Altmüller, J., Schulze, N., Pfander, B., & Boos, D. (2021). MTBP phosphorylation controls DNA replication origin firing. doi.org. https://doi.org/10.1038/s41598-021-83287-w
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Ciardo, D., Haccard, O., Narassimprakash, H., Arbona, J., Hyrien, O., Audit, B., Marheineke, K., & Goldar, A. (2020). Organization of DNA Replication Origin Firing in Xenopus Egg Extracts: The Role of Intra-S Checkpoint. doi.org. https://doi.org/10.3390/genes12081224
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Chetlangia, N., Thakur, B. L., Redon, C. E., Zinder, O., Mishra, M., Liu, D., Pongor, L., Song, Y. J., Asoudegi, D., Fields, C. J., Prasanth, K., Aladjem, M., & Prasanth, S. (2026). Polycomb-mediated 3D-genome organization controls replication timing. doi.org. https://doi.org/10.1126/sciadv.adx7445
What does the evidence say?
The retrieved papers consistently show that checkpoint kinases (such as Chk1) and pre-replication complexes regulate DNA replication timing and origin firing. The evidence heavily supports the claim, with no papers offering refutation.
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