PTSD recovery is correlated with changes in prefrontal cortex blood flow
Is it true that PTSD recovery is correlated with changes in prefrontal cortex blood flow?
Yes. Multiple neuroimaging studies indicate that posttraumatic stress disorder (PTSD) recovery and symptom reduction are correlated with dynamic changes in cerebral blood flow and neural activation within prefrontal cortical regions.
Verdict: SUPPORTED · 3 sources for, 0 against · Last checked
The retrieved literature directly supports the claim that PTSD recovery correlates with changes in prefrontal cortex blood flow or activation. Specifically, papers [0], [1], and [7] report longitudinal or treatment-related changes in prefrontal perfusion and functioning that correspond with symptom improvement or recovery. No papers refute this relationship.
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Osuch, E., Willis, M., Bluhm, R., Ursano, R., & Drevets, W. (2008). Neurophysiological responses to traumatic reminders in the acute aftermath of serious motor vehicle collisions using [15O]-H2O PET. doi.org. https://doi.org/10.1016/j.biopsych.2008.03.010
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Fani, N., Fani, N., Ashraf, A., Afzal, N., Jawed, F., Kitayama, N., Reed, L., & Bremner, J. (2011). Increased Neural Response to Trauma Scripts in Posttraumatic Stress Disorder Following Paroxetine Treatment: A Pilot Study. doi.org. https://doi.org/10.1016/j.neulet.2011.01.037
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Yoon, S., Won, W., Lee, S., Han, K., Ha, E., Lee, J., Hyeon, S. J., Joo, Y., Hong, H., Lee, H., Song, Y., Park, K. D., Huber, B. R., Lee, J., Edden, R., Suh, M., Ryu, H., Lee, C. J., & Lyoo, I. (2025). Astrocytic gamma-aminobutyric acid dysregulation as a therapeutic target for posttraumatic stress disorder. doi.org. https://doi.org/10.1038/s41392-025-02317-5
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