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the claim

Protons are incorporated during the biological reduction of NAD

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that protons are incorporated during the biological reduction of NAD?

Yes. Protons are incorporated alongside electrons during the biological reduction of NAD(P)+ to NAD(P)H, as established in biochemical literature.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

The analysis

The claim addresses the incorporation of protons during the biological reduction of NAD. Paper [1] notes that NAD(P)H is involved in proton and electron transmission, and Paper [9] details the reduction mechanism involving electron and proton sources to form NAD(P)H. Both support the claim directly and fully.

Evidence for · 2
Chiral and Regenerable NAD(P)H Models Enabled Biomimetic Asymmetric Reduction: Design, Synthesis, Scope and Mechanistic Studies.
2019
States that NAD(P)H plays an important role in both electron and proton transmission within the cell.
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Wang, J., Zhao, Z., Zhao, Y., Luo, G., Zhu, Z., Luo, Y., & Zhou, Y. (2019). Chiral and Regenerable NAD(P)H Models Enabled Biomimetic Asymmetric Reduction: Design, Synthesis, Scope and Mechanistic Studies.. doi.org. https://doi.org/10.1021/acs.joc.9b03054

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More for · 1
Catalytic reduction of NAD(P)+ to NAD(P)H.
2025
Discusses mechanisms where electrons and protons are transferred to produce 1,4-NAD(P)H.
Get citation
Fukuzumi, S., Lee, Y., & Nam, W. (2025). Catalytic reduction of NAD(P)+ to NAD(P)H.. doi.org. https://doi.org/10.1039/d4cc06254j

Receipt History
first checked05 Aug 2026
judged → SUPPORTED · 7205 Aug 2026
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