Multiple biological and medical reviews establish that post-traumatic stress disorder is accompanied by profound physiological effects, including autonomic nervous system dysfunction, hypothalamic-pituitary-adrenal axis abnormalities, systemic inflammation, and metabolic changes.
The claim states that PTSD causes extreme physiological effects. The retrieved literature extensively documents various severe physiological consequences associated with PTSD, including autonomic nervous system dysregulation, HPA axis disruption, neuroendocrine changes, immune alterations, and metabolic syndrome links. The evidence consistently supports the claim across numerous review papers and studies.