Pharmaceutical drugs expire due to chemical degradation over time
the verdict
SUPPORTED
the evidence backs this
confidence 81/100
Pharmaceutical drugs undergo chemical degradation over time when exposed to various environmental factors, which affects their shelf life and stability.
Evidence for · 5
A Novel Stability-Indicating HPLC Method with Kinetics Study for the Concurrent Analysis of Anti-Hypertensive Drug Combination of Atenolol and Indapamide.
2025 · cited by 8
Paper 0 establishes that antihypertensive drugs degrade under various stress conditions, necessitating stability-indicating methods.
See more details
More for · 4
Thermal Stability and Kinetics of Degradation of Moxonidine as Pure Ingredient vs. Pharmaceutical Formulation
2023 · cited by 4
Paper 1 investigates thermal stability and degradation kinetics of active pharmaceutical ingredients and formulations over time.
A Risk-Based Framework for Hospital Compounding: Integrating Degradation Mechanisms and Predictive Toxicology.
2025 · cited by 1
Paper 3 notes that drug substances can undergo rapid degradation under alternative conditions such as light, moisture, or specific excipients.
Stability-Indicating RP-HPLC Method Development for A Fixed-Dose Combination Tablet and Its Degradation Kinetics
2025 · cited by 1
Paper 4 analyzes the degradation kinetics of active pharmaceutical ingredients in fixed-dose combination tablets under different stress conditions.
Hydrolytic stress degradation study and concomitant HPTLC estimation of thioctic acid and biotin in their combined capsules: greenness, blueness and whiteness assessment.
2025 · cited by 0
Paper 9 evaluates hydrolytic degradation kinetics in fresh and expired combined pharmaceutical capsules.