Lithium treatment causes long-term adverse effects on kidney function.
the verdict
SUPPORTED
the evidence backs this
confidence 75/100
Evidence consistently shows that long-term lithium treatment is associated with adverse effects on renal function, including reduced eGFR and a risk of chronic tubulointerstitial kidney injury.
Evidence for · 3
Diagnosis and Management of Acute and Chronic Lithium-Associated Nephrotoxicity.
2026 · cited by 0
Indicates that chronic lithium use is associated with a tubulointerstitial pattern of kidney injury and chronic kidney disease after a latency period.
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More for · 2
Lithium nephrotoxicity: a systematic review and meta-analysis of lithium versus non-lithium control studies in patients with affective disorders.
2026 · cited by 0
Demonstrates through meta-analysis that patients taking lithium exhibit less favorable eGFR outcomes compared to non-lithium control groups.
Could Lithium Be Preserved for the Stabilization of Bipolar Patients?
2026 · cited by 0
Acknowledges that glomerular filtration rate decline is a notable adverse effect of continuous, long-term lithium administration.