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the claim

Different laboratories use varying reference ranges for thyroid antibodies

the verdict

SUPPORTED

the evidence backs this

confidence 84/100

Different laboratories and analytical assay platforms utilize varying reference limits and cutoffs for thyroid autoantibodies like TgAb and anti-TPO, meaning results cannot always be used interchangeably.

Evidence for · 2

Definition of the upper reference limit for thyroglobulin antibodies according to the National Academy of Clinical Biochemistry guidelines: comparison of eleven different automated methods

2017 · cited by 29

Paper 1 demonstrates significant inter-method variability and wide variation in upper reference limits and cutoffs for thyroglobulin antibodies across multiple automated assay platforms and laboratories.

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More for · 1

Anti-thyroid peroxidase (TPO) antibodies – Comparative analysis of two automatic methods, ECLIA and CMIA

2024 · cited by 5

Paper 7 confirms that different analytical methods for anti-thyroid peroxidase (TPO) antibodies possess differing reference ranges and lack quantitative agreement, making them unsuitable for interchangeable monitoring.

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first checked02 Aug 2026

judged → SUPPORTED · 8402 Aug 2026

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