Clinical literature confirms that patients can develop pharmacological tolerance, often termed tachyphylaxis, during long-term treatment with psychiatric medications such as antidepressants, leading to a reduced therapeutic response over time.
The claim states that patients develop pharmacological tolerance or immunity to psychiatric drugs. Papers [1], [4], and [11] explicitly discuss antidepressant tolerance and tachyphylaxis, where patients lose initial response and experience symptom relapse despite ongoing treatment. No retrieved papers refute the existence of tolerance or tachyphylaxis in psychiatric medications. Therefore, the balance verdict is SUPPORTED.