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the claim

Orthologous proteins exhibit functional divergence across different species.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Orthologous proteins exhibit functional divergence across different species?

Yes. Comparative genomic and transcriptomic studies across various species demonstrate that orthologous proteins frequently exhibit functional and regulatory divergence.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently supports the claim that orthologous proteins undergo functional divergence, as shown by studies examining gene expression patterns, transcriptional regulation, and protein embeddings across different species.

Evidence for · 3
2019
The study demonstrates that orthologous genes in Pyrus species exhibit functional divergence and subfunctionalization in their expression profiles.
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Cao, Y., Jiang, L., Wang, L., & Cai, Y. (2019). Evolutionary Rate Heterogeneity and Functional Divergence of Orthologous Genes in Pyrus. doi.org. https://doi.org/10.3390/biom9090490

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More for · 2
2026
Comparative proteome analysis using protein language models reveals proteome-scale functional divergence among orthologous proteins.
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T, E., GA, C., K, K., D, E., & H, T. (2026). Protein Language Model Embeddings Reveal Proteome-Scale Ortholog Divergence Relevant to Cross-Species Pharmacology. doi.org. https://doi.org/10.20944/preprints202606.1966.v1

2026
The research shows transcriptional divergence among conserved orthologous starch metabolism genes across rice subspecies.
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MS, K., JY, K., D, S., KK, K., & YG, C. (2026). Transcriptional Divergence of Conserved Starch Metabolism Genes During Grain Filling in <i>Indica</i> and <i>Japonica</i> Rice.. doi.org. https://doi.org/10.3390/cimb48050436

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What does the evidence say?

The retrieved literature consistently supports the claim that orthologous proteins undergo functional divergence, as shown by studies examining gene expression patterns, transcriptional regulation, and protein embeddings across different species.

Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 8204 Aug 2026
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