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the claim

Neurons possess mechanisms to temporarily increase membrane resistance

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that neurons possess mechanisms to temporarily increase membrane resistance?

Yes. Neurons utilize various regulatory mechanisms, such as ion channel modulation during hypoxic events or changes in ionic currents, to temporarily alter their membrane resistance.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

The analysis

The claim states that neurons possess mechanisms to temporarily increase membrane resistance. Multiple papers (such as [2], which notes that hypoxia and cytokine modulation can increase input resistance, and [3], which discusses how reducing h-current increases membrane input resistance) provide direct evidence supporting this physiological capability.

Evidence for · 2
Anti-hypoxic effect of interleukin-10 in hippocampal neurons is mediated by modulation of TASK-1 and TASK-3 channels activity.
2022
The paper demonstrates that brief hypoxic episodes can cause a significant increase in neuronal membrane input resistance.
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Konakov, M. V., Teplov, I., Levin, S., & Nenov, M. (2022). Anti-hypoxic effect of interleukin-10 in hippocampal neurons is mediated by modulation of TASK-1 and TASK-3 channels activity.. doi.org. https://doi.org/10.1016/j.bbrc.2022.05.051

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More for · 1
H-current modulation of cortical Up and Down states
2024
The paper shows that reducing h-current leads to an increased input resistance in neurons, modulating network activity.
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Porta, L. D., Barbero-Castillo, A., Sanchez-Sanchez, J. M., Cancino, N., & Sanchez-Vives, M. V. (2024). H-current modulation of cortical Up and Down states. doi.org. https://doi.org/10.1113/JP287616

What does the evidence say?

The claim states that neurons possess mechanisms to temporarily increase membrane resistance. Multiple papers (such as [2], which notes that hypoxia and cytokine modulation can increase input resistance, and [3], which discusses how reducing h-current increases membrane input resistance) provide direct evidence supporting this physiological capability.

Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 8004 Aug 2026
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