Neural connectivity strongly correlates with neurological function
Is it true that neural connectivity strongly correlates with neurological function?
Yes. Multiple neuroimaging and clinical studies demonstrate that structural and functional neural connectivity metrics strongly correlate with and predict neurological and cognitive function.
Verdict: SUPPORTED · 8 sources for, 0 against · Last checked
The retrieved papers consistently provide empirical evidence supporting the claim that neural connectivity (whether structural white matter integrity, gray matter microstructure, or structure-function coupling) strongly correlates with neurological and cognitive function across normal aging, neurodegenerative diseases, traumatic brain injury, and psychiatric disorders. All relevant papers support the relationship, and none refute it.
Get citation
Voineskos, A., Rajji, T., Lobaugh, N., Miranda, D., Shenton, M., Kennedy, J., Pollock, B., & Mulsant, B. (2010). Age-related decline in white matter tract integrity and cognitive performance: A DTI tractography and structural equation modeling study. doi.org. https://doi.org/10.1016/j.neurobiolaging.2010.02.009
See more details
Get citation
Rivero, A. J. P., Cantero, J., Atienza, M., & García-Ojalvo, J. (2010). Relating structural and functional anomalous connectivity in the aging brain via neural mass modeling. doi.org. https://doi.org/10.1016/j.neuroimage.2009.12.105
Get citation
Koubiyr, I., Deloire, M., Brochet, B., Besson, P., Charre-Morin, J., Saubusse, A., Tourdias, T., & Ruet, A. (2020). Structural constraints of functional connectivity drive cognitive impairment in the early stages of multiple sclerosis. doi.org. https://doi.org/10.1177/1352458520971807
Get citation
Butti, E., Cattaneo, S., Bacigaluppi, M., Cambiaghi, M., Scotti, G., Brambilla, E., Ruffini, F., Sferruzza, G., Ripamonti, M., Simeoni, F., Cacciaguerra, L., Zanghì, A., Quattrini, A., Fesce, R., Panina-Bordignon, P., Giannese, F., Cittaro, D., Kuhlmann, T., D’Adamo, P., Rocca, M., Taverna, S., & Martino, G. (2022). Neural precursor cells tune striatal connectivity through the release of IGFBPL1. doi.org. https://doi.org/10.1038/s41467-022-35341-y
Get citation
Ahmed, I., Reeves, W. D., LaBalle, M., Taber, M. F., Sneed, S. E., Kaiser, E. E., West, F. D., & Zhao, Q. (2025). A Novel Integration of Brain Structural and Functional Connectivity for Identifying Traumatic Brain Injury Induced Perturbations. doi.org. https://doi.org/10.1016/j.jneumeth.2025.110459
Get citation
Lyall, D. M., Russell, E., Ward, J., & Stewart, W. (2024). A history of traumatic brain injury is associated with poorer cognition and imaging evidence of altered white matter tract integrity in UK Biobank (n = 50 376). doi.org. https://doi.org/10.1093/braincomms/fcae363
Get citation
Marian, O. C., Matis, S., Dobson-Stone, C., Kim, W. S., Kwok, J. B., Piguet, O., Halliday, G., Landin-Romero, R., & Don, A. S. (2025). Reduced plasma hexosylceramides in frontotemporal dementia are a biomarker of white matter integrity. doi.org. https://doi.org/10.1002/dad2.70131
Get citation
Nagai, Y., Fujimura, T., Uchida, W., Iseki, R., Kamagata, K., Aoki, S., & Kato, T. (2025). Gray matter microstructure alterations with excess extra-cellular free water contribute to cognitive dysfunction in bipolar disorder: A comparative analysis with white matter pathology. doi.org. https://doi.org/10.1016/j.neuroimage.2025.121342
What does the evidence say?
The retrieved papers consistently provide empirical evidence supporting the claim that neural connectivity (whether structural white matter integrity, gray matter microstructure, or structure-function coupling) strongly correlates with neurological and cognitive function across normal aging, neurodegenerative diseases, traumatic brain injury, and psychiatric disorders. All relevant papers support the relationship, and none refute it.
Receipt History
Challenge the receipt
Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.
Terms · Privacy · How verdicts work