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the claim

Melatonin acts as a therapeutic antioxidant in diabetes

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that melatonin acts as a therapeutic antioxidant in diabetes?

Yes. Multiple studies demonstrate that melatonin exerts therapeutic antioxidant and anti-inflammatory effects in diabetes, mitigating complications such as oxidative stress, tissue damage, and inflammation.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked

The analysis

The retrieved papers consistently provide experimental and clinical evidence showing that melatonin acts as a beneficial antioxidant and anti-inflammatory agent in diabetes models and patient populations, reducing oxidative stress markers and protecting against diabetes-associated organ damage. There are no papers refuting this claim.

Evidence for · 5
Protective effects of melatonin on stroke in diabetic mice: central and peripheral inflammation modulation.
2025
Melatonin reduces ischemic brain damage and moderates inflammatory responses in diabetic mice.
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C, L., J, G., L, G., J, L., B, X., & H, Z. (2025). Protective effects of melatonin on stroke in diabetic mice: central and peripheral inflammation modulation.. doi.org. https://doi.org/10.1136/svn-2024-003442

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More for · 4
Sources of Polyphenols with Potential α-Glucosidase-Inhibitory Activities from Thai Local Edible Plants: In Vitro and Network Pharmacology Approaches.
2026
Plant analyses identify melatonin and other polyphenols as contributory compounds with antioxidant and antidiabetic properties.
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P, P., J, R., P, S., M, S., P, P., P, S., T, P., S, T., V, L., & B, S. (2026). Sources of Polyphenols with Potential α-Glucosidase-Inhibitory Activities from Thai Local Edible Plants: In Vitro and Network Pharmacology Approaches.. doi.org. https://doi.org/10.3390/plants15111721

Effect of Melatonin as an Adjunct to NSPT on Periodontal and Systemic Outcomes in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of RCTs.
2026
Systemic melatonin supplementation as an adjunct to periodontal therapy improves oxidative stress and glycemic control markers in patients with type 2 diabetes.
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T, A. & YA, B. (2026). Effect of Melatonin as an Adjunct to NSPT on Periodontal and Systemic Outcomes in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of RCTs.. doi.org. https://doi.org/10.3390/jcm15114071

Melatonin Supplementation in Iranian Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Exploring Oxidative Stress and Inflammation.
2026
Melatonin supplementation significantly reduces oxidative stress markers such as malondialdehyde while increasing total antioxidant capacity in diabetic patients.
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SS, B., R, M. F., A, A., R, K., M, R., MR, D., M, R., & K, H. (2026). Melatonin Supplementation in Iranian Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Exploring Oxidative Stress and Inflammation.. doi.org. https://doi.org/10.4103/ijpvm.ijpvm_72_24

Melatonin and Quercetin Co-Treatment Attenuates Hepatic Damage in Diabetic Rats by Mitigating Oxidative Stress and Inflammation.
2026
Melatonin treatment mitigates oxidative stress and inflammation, protecting against hepatic damage in diabetic rats.
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ÉR, A., JGMD, S., IMF, M., LCDS, S., MMS, F., CL, N., VB, M., FAL, S., LD, V., ÁAC, T., & VW, T. (2026). Melatonin and Quercetin Co-Treatment Attenuates Hepatic Damage in Diabetic Rats by Mitigating Oxidative Stress and Inflammation.. doi.org. https://doi.org/10.1002/jbt.70855

What does the evidence say?

The retrieved papers consistently provide experimental and clinical evidence showing that melatonin acts as a beneficial antioxidant and anti-inflammatory agent in diabetes models and patient populations, reducing oxidative stress markers and protecting against diabetes-associated organ damage. There are no papers refuting this claim.

Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 7804 Aug 2026
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