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the claim

Lactate dehydrogenase differentiates exudates from transudates

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that lactate dehydrogenase differentiates exudates from transudates?

Yes. Multiple clinical studies confirm that lactate dehydrogenase (LDH) is a standard and effective biomarker used to differentiate between exudative and transudative pleural effusions, both in Light's criteria and in newer fluid-only criteria.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked

The analysis

The retrieved papers consistently demonstrate that lactate dehydrogenase (LDH) measurements, whether alone or in combination with other markers such as cholesterol or total protein, are widely used and effective for differentiating between exudates and transudates. No papers refute the claim.

Evidence for · 5
Simplified Criteria Using Pleural Fluid Cholesterol and Lactate Dehydrogenase to Distinguish between Exudative and Transudative Pleural Effusions
2019
The study evaluates criteria combining pleural fluid lactate dehydrogenase to distinguish between exudates and transudates.
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Lépine, P., Thomas, R., Nguyen, S., Lacasse, Y., Cheah, H. M., Creaney, J., Muruganandan, S., Martel, S., Lee, Y., & Delage, A. (2019). Simplified Criteria Using Pleural Fluid Cholesterol and Lactate Dehydrogenase to Distinguish between Exudative and Transudative Pleural Effusions. doi.org. https://doi.org/10.1159/000496396

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More for · 4
Combined pleural fluid cholesterol and total protein in differentiation of exudates and transudates.
2022
Pleural fluid lactate dehydrogenase levels are measured along with other parameters to successfully differentiate between exudates and transudates.
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Patel, A. K. & Choudhury, S. (2022). Combined pleural fluid cholesterol and total protein in differentiation of exudates and transudates.. doi.org. https://doi.org/10.5005/ijcdas-55-1-21

Categorisation of pleural fluids in routine clinical practice: analysis of pleural fluid protein and lactate dehydrogenase alone compared with modified Light’s criteria
2008
Pleural fluid lactate dehydrogenase is used directly in criteria to categorise pleural fluids as either exudates or transudates.
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Murphy, M. J. & Jenkinson, F. (2008). Categorisation of pleural fluids in routine clinical practice: analysis of pleural fluid protein and lactate dehydrogenase alone compared with modified Light’s criteria. doi.org. https://doi.org/10.1136/jcp.2007.051318

Comparison of the Efficacy of Light’s Criteria With Serum-Effusion Albumin Gradient and Pleural Effusion Glucose
2023
Pleural fluid lactate dehydrogenase is measured alongside protein and albumin to accurately categorize pleural effusions as transudates or exudates.
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Sharma, K., Fultariya, L. K., Mallimala, P. R., Shah, K., & Sharma, V. (2023). Comparison of the Efficacy of Light’s Criteria With Serum-Effusion Albumin Gradient and Pleural Effusion Glucose. doi.org. https://doi.org/10.7759/cureus.43319

Revisiting Light's criteria: a validated blood-free triple combination matches diagnostic accuracy in over 7000 patients.
2026
Lactate dehydrogenase is a core component of both double and triple combinations used to distinguish exudative from transudative pleural effusions.
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JM, P., L, P., R, P., & S, B. (2026). Revisiting Light's criteria: a validated blood-free triple combination matches diagnostic accuracy in over 7000 patients.. doi.org. https://doi.org/10.1183/23120541.00821-2025

What does the evidence say?

The retrieved papers consistently demonstrate that lactate dehydrogenase (LDH) measurements, whether alone or in combination with other markers such as cholesterol or total protein, are widely used and effective for differentiating between exudates and transudates. No papers refute the claim.

Receipt History
first checked06 Aug 2026
judged → SUPPORTED · 8306 Aug 2026
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