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the claim

Inward rectifier potassium channels regulate cardiac action potentials

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that inward rectifier potassium channels regulate cardiac action potentials?

Yes. Inward rectifier potassium channels play a critical role in regulating the resting membrane potential, action potential duration, and overall electrophysiological stability of cardiac tissue.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently supports the claim that inward rectifier potassium channels regulate cardiac action potentials. Papers 0, 1, and 9 specifically detail how these channels govern resting membrane potential, action potential duration, and cardiac excitability. No retrieved papers contradict this well-established physiological principle.

Evidence for · 3
Inward Rectifier Potassium Channels Control Rotor Frequency in Ventricular Fibrillation
2009
This paper demonstrates that inward rectifier potassium currents (IK1) are crucial for regulating cardiac excitability, action potential duration, and the stability of reentry during ventricular fibrillation.
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Jalife, J. (2009). Inward Rectifier Potassium Channels Control Rotor Frequency in Ventricular Fibrillation. doi.org. https://doi.org/10.1016/j.hrthm.2009.07.019

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More for · 2
Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents.
2020
This study establishes that Kir2.1 inward rectifier potassium channels are key regulators of the resting membrane potential and ventricular action potential duration in the human heart.
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Park, S., Ponce-Balbuena, D., Kuick, R., Guerrero-Serna, G., Yoon, J., Mellacheruvu, D., Conlon, K., Basrur, V., Nesvizhskii, A., Jalife, J., & Rual, J. (2020). Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents.. doi.org. https://doi.org/10.1074/mcp.RA120.002071

Role of Potassium Ion Channels in Vascular Tone Regulation and Hypertension.
2026
This review highlights that potassium currents, including inward-rectifier channels, play a vital role in regulating cardiac action potentials, refractory periods, and preventing arrhythmogenesis.
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T, M. G., S, T., KS, B., & J, G. (2026). Role of Potassium Ion Channels in Vascular Tone Regulation and Hypertension.. doi.org. https://doi.org/10.1161/atvbaha.125.324059

Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 8504 Aug 2026
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