Inbreeding is highly efficient at increasing homozygosity in populations.
Is it true that inbreeding is highly efficient at increasing homozygosity in populations?
Yes. Inbreeding consistently increases homozygosity within populations, a process frequently measured and tracked via runs of homozygosity (ROH) and autozygosity across diverse species.
Verdict: SUPPORTED · 6 sources for, 0 against · Last checked
The retrieved papers consistently support the claim that inbreeding increases homozygosity, frequently discussing it through the lens of runs of homozygosity (ROH), autozygosity, and identity by descent. None of the sources refute the premise. Therefore, the balance verdict is SUPPORTED.
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Addo, S., Klingel, S., Thaller, G., & Hinrichs, D. (2021). Genetic diversity and the application of runs of homozygosity-based methods for inbreeding estimation in German White-headed Mutton sheep. doi.org. https://doi.org/10.1371/journal.pone.0250608
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Atağ, G., Kaptan, D., Yüncü, E., Vural, K. B., Mereu, P., Pirastru, M., Barbato, M., Leoni, G., Güler, M. N., Er, T., Eker, E., Yazici, T. D., Kılıç, M. S., Altınışık, N. E., Çelik, E., Miranda, P. M., Dehasque, M., Floridia, V., Götherström, A., Bilgin, C. C., Togan, I., Günther, T., Özer, F., Hadjisterkotis, E., & Somel, M. (2023). Population Genomic History of the Endangered Anatolian and Cyprian Mouflons in Relation to Worldwide Wild, Feral, and Domestic Sheep Lineages. doi.org. https://doi.org/10.1093/gbe/evae090
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Zeitler, L. & Gilbert, K. J. (2024). Using runs of homozygosity and machine learning to disentangle sources of inbreeding and infer self-fertilization rates. doi.org. https://doi.org/10.1101/2024.02.20.581206
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Q, H., J, D., FR, S., H, P., & NK, K. (2026). Genomic partitioning and functional dissection of inbreeding depression for stature in Brown Swiss cattle.. doi.org. https://doi.org/10.1186/s12711-026-01062-9
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Sweetalana, S, N., S, H., JA, M., & ZA, S. (2026). Genotypic and phenotypic consequences of domestication in dogs.. doi.org. https://doi.org/10.1093/g3journal/jkag195
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L, G., S, B., M, K., A, U., K, A., & O, L. (2026). Evolution of Methods for the Quantitative Assessment of Inbreeding in Livestock.. doi.org. https://doi.org/10.3390/biology15070530
What does the evidence say?
The retrieved papers consistently support the claim that inbreeding increases homozygosity, frequently discussing it through the lens of runs of homozygosity (ROH), autozygosity, and identity by descent. None of the sources refute the premise. Therefore, the balance verdict is SUPPORTED.
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