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the claim

Hormones activating adenylyl cyclase produce diverse cellular effects through distinct downstream signaling pathways.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that hormones activating adenylyl cyclase produce diverse cellular effects through distinct downstream signaling pathways?

Yes. Multiple studies demonstrate that hormones and effectors activating adenylyl cyclase generate cyclic AMP, which subsequently engages diverse downstream signaling pathways to regulate cellular functions.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

The analysis

The retrieved papers provide robust support for the claim that hormones or related effectors activating adenylyl cyclase (and thus modulating cAMP) trigger diverse downstream cellular signaling pathways (such as PKA, MAPK, and various transcriptional regulators) leading to varied cellular effects.

Evidence for · 3
Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathways
2019
Demonstrates that hormone- or compound-induced cAMP activation stimulates distinct downstream pathways such as PKA/CREB and MAPK to mediate biological effects like melanogenesis.
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Hwang, Y., Oh, S., Park, S., Lee, J., Yoo, J., Kwon, K., Park, S. J., Kim, J., Yu, E., Cho, J., & Lee, J. (2019). Melanogenic Effects of Maclurin Are Mediated through the Activation of cAMP/PKA/CREB and p38 MAPK/CREB Signaling Pathways. doi.org. https://doi.org/10.1155/2019/9827519

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More for · 2
The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformability
2019
Shows that adenylyl cyclase stimulation and subsequent cAMP elevation activate complex molecular signaling cascades that regulate red blood cell micromechanical properties.
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Semenov, A., Shirshin, E., Muravyov, A., & Priezzhev, A. (2019). The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformability. doi.org. https://doi.org/10.3389/fphys.2019.00923

The ulcerative colitis risk gene adenylyl cyclase 7 restrains the T-helper 2 phenotype and Class II antigen presentation.
2025
Indicates that adenylyl cyclase generates cyclic AMP downstream of GPCR signaling, which in turn influences diverse cellular processes including cytokine production and antigen presentation.
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CJ, C., Y, L., A, K., A, S., VJ, W., & H, H. (2025). The ulcerative colitis risk gene adenylyl cyclase 7 restrains the T-helper 2 phenotype and Class II antigen presentation.. doi.org. https://doi.org/10.1093/ecco-jcc/jjaf030

What does the evidence say?

The retrieved papers provide robust support for the claim that hormones or related effectors activating adenylyl cyclase (and thus modulating cAMP) trigger diverse downstream cellular signaling pathways (such as PKA, MAPK, and various transcriptional regulators) leading to varied cellular effects.

Receipt History
first checked05 Aug 2026
judged → SUPPORTED · 8605 Aug 2026
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