Hebbian learning strengthens synapses based on simultaneous neuronal firing.
Is it true that Hebbian learning strengthens synapses based on simultaneous neuronal firing?
Yes. Extensive neuroscientific literature confirms that Hebbian learning mechanisms strengthen synapses based on the precise timing and simultaneous firing of pre- and postsynaptic neurons.
Verdict: SUPPORTED · 7 sources for, 0 against · Last checked
The retrieved papers provide robust, consistent empirical support for spike timing-dependent plasticity (STDP) and Hebbian learning rules, where synchronous pre- and postsynaptic activity dictates synaptic strengthening or weakening. There are no refuting studies in the provided set.
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Carlisle, H. J., Fink, A. E., Grant, S. G. N., & O’Dell, T. J. (2008). Opposing effects of PSD‐93 and PSD‐95 on long‐term potentiation and spike timing‐dependent plasticity. doi.org. https://doi.org/10.1113/jphysiol.2008.163469
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Valtcheva, S. & Venance, L. (2016). Astrocytes gate Hebbian synaptic plasticity in the striatum. doi.org. https://doi.org/10.1038/ncomms13845
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Luu, P. & Malenka, R. C. (2008). Spike Timing-Dependent Long-Term Potentiation in Ventral Tegmental Area Dopamine Cells Requires PKC. doi.org. https://doi.org/10.1152/jn.01384.2007
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Stoler, O., Stavsky, A., Khrapunsky, Y., Melamed, I., D, G. E. S. P., Gitler, D., Sekler, I., & Fleidervish, I. (2022). Frequency- and spike-timing-dependent mitochondrial Ca2+ signaling regulates the metabolic rate and synaptic efficacy in cortical neurons. doi.org. https://doi.org/10.7554/eLife.74606
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Krueger, J., Krauth, R., Reichert, C., Perdikis, S., Vogt, S., Huchtemann, T., Dürschmid, S., Sickert, A., Lamprecht, J., Huremović, A., Görtler, M., Nasuto, S., Tsai, I., Knight, R. T., Hinrichs, H., Heinze, H., Lindquist, S., Sailer, M., Millán, J. D. R., & Sweeney-Reed, C. (2023). Hebbian plasticity induced by temporally coincident BCI enhances post-stroke motor recovery. doi.org. https://doi.org/10.1038/s41598-024-69037-8
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Ruan, H. & Yao, W. (2017). Cocaine Promotes Coincidence Detection and Lowers Induction Threshold during Hebbian Associative Synaptic Potentiation in Prefrontal Cortex. doi.org. https://doi.org/10.1523/JNEUROSCI.2257-16.2016
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E, P., S, M., D, D. D., T, S., F, P., & E, D. (2025). Coincidence detection between apical and basal dendrites drives STDP in cerebellar Golgi cells.. doi.org. https://doi.org/10.1038/s42003-025-08153-1
What does the evidence say?
The retrieved papers provide robust, consistent empirical support for spike timing-dependent plasticity (STDP) and Hebbian learning rules, where synchronous pre- and postsynaptic activity dictates synaptic strengthening or weakening. There are no refuting studies in the provided set.
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