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the claim

Ginkgo biloba interacts negatively with prescription psychotropic drugs

the verdict
SUPPORTED
the evidence backs this
Recorded sources
5 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Ginkgo biloba interacts negatively with prescription psychotropic drugs?

Yes. Multiple clinical reviews and case reports demonstrate that Ginkgo biloba can interact negatively with prescription psychotropic and antidepressant medications, increasing the risk of adverse effects such as bleeding complications and altered drug metabolism.

Verdict: SUPPORTED · 5 sources for, 0 against · Last checked

The analysis

The claim is specific and falsifiable, passing Step 0. The retrieved literature (e.g., papers 1, 3, 5, 8, and 10) consistently documents that Ginkgo biloba causes pharmacokinetic and pharmacodynamic herb-drug interactions, particularly with psychotropic medications like antidepressants (SSRIs/SNRIs) and sedatives, leading to adverse clinical outcomes.

Evidence for · 5
Unwanted effects of psychotropic drug interactions with medicinal products and diet supplements containing plant extracts.
2018
This study analyzes adverse drug interactions involving herbal preparations and psychotropic drugs, finding that Ginkgo biloba frequently causes hemorrhagic complications when combined with SSRIs or SNRIs.
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Woroń, J. & Siwek, M. (2018). Unwanted effects of psychotropic drug interactions with medicinal products and diet supplements containing plant extracts.. doi.org. https://doi.org/10.12740/PP/OnlineFirst/80998

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More for · 4
Herb-Drug Interactions and Their Impact on Pharmacokinetics: an Update.
2023
This review highlights Ginkgo biloba among major herbs known to cause herb-drug interactions by affecting pharmacokinetic and pharmacodynamic processes.
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Li, Y., Cheng, W., Xia, K., & Wu, S. (2023). Herb-Drug Interactions and Their Impact on Pharmacokinetics: an Update.. doi.org. https://doi.org/10.2174/1389200224666230116113240

Pharmacokinetic and pharmacodynamic herb-drug interactions-part I. Herbal medicines of the central nervous system.
2023
This review discusses potential drug interactions between central nervous system-active herbal medicines, including Ginkgo, and conventional pharmaceuticals.
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S, C., M, N., P, M., & J, T. (2023). Pharmacokinetic and pharmacodynamic herb-drug interactions-part I. Herbal medicines of the central nervous system.. doi.org. https://doi.org/10.7717/peerj.16149

Role of herbal extracts in modulating drug metabolism: implications for pharmacokinetics, enzyme regulation, and therapeutic outcome
2025
This article notes that Ginkgo biloba can alter drug-metabolizing enzymes such as cytochrome P450, leading to clinically significant interactions and altered therapeutic outcomes.
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Khan, A., Al-Hamoud, G. A., Amina, M., Alam, P., Hawwal, M., & Fantoukh, O. I. (2025). Role of herbal extracts in modulating drug metabolism: implications for pharmacokinetics, enzyme regulation, and therapeutic outcome. doi.org. https://doi.org/10.1080/03602532.2025.2603936

Herb Drug Interaction in Antibiotic Drug, Antiulcer Drug, Antihypertensive Drug, Antidiabetic Drug, Anticancer Drug
2023
This review documents specific severe interactions, noting that Ginkgo biloba combined with prescription drugs like trazodone can lead to serious adverse events.
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Doke, C. O., Tiwari, R. S., Todekar, V. B., Mane, A. P., Sawant, V. S., & Sawant, G. V. (2023). Herb Drug Interaction in Antibiotic Drug, Antiulcer Drug, Antihypertensive Drug, Antidiabetic Drug, Anticancer Drug. doi.org. https://doi.org/10.52711/2349-2988.2023.00020

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Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 8504 Aug 2026
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