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the claim
Ginkgo biloba interacts negatively with prescription psychotropic drugs
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
5 sources for · 0 against

Multiple clinical reviews and case reports demonstrate that Ginkgo biloba can interact negatively with prescription psychotropic and antidepressant medications, increasing the risk of adverse effects such as bleeding complications and altered drug metabolism.

Evidence for · 5
Unwanted effects of psychotropic drug interactions with medicinal products and diet supplements containing plant extracts.
2018 · cited by 43
This study analyzes adverse drug interactions involving herbal preparations and psychotropic drugs, finding that Ginkgo biloba frequently causes hemorrhagic complications when combined with SSRIs or SNRIs.
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The analysis

The claim is specific and falsifiable, passing Step 0. The retrieved literature (e.g., papers 1, 3, 5, 8, and 10) consistently documents that Ginkgo biloba causes pharmacokinetic and pharmacodynamic herb-drug interactions, particularly with psychotropic medications like antidepressants (SSRIs/SNRIs) and sedatives, leading to adverse clinical outcomes.

More for · 4
Herb-Drug Interactions and Their Impact on Pharmacokinetics: an Update.
2023 · cited by 30
This review highlights Ginkgo biloba among major herbs known to cause herb-drug interactions by affecting pharmacokinetic and pharmacodynamic processes.
Pharmacokinetic and pharmacodynamic herb-drug interactions-part I. Herbal medicines of the central nervous system.
2023 · cited by 13
This review discusses potential drug interactions between central nervous system-active herbal medicines, including Ginkgo, and conventional pharmaceuticals.
Role of herbal extracts in modulating drug metabolism: implications for pharmacokinetics, enzyme regulation, and therapeutic outcome
2025 · cited by 5
This article notes that Ginkgo biloba can alter drug-metabolizing enzymes such as cytochrome P450, leading to clinically significant interactions and altered therapeutic outcomes.
Herb Drug Interaction in Antibiotic Drug, Antiulcer Drug, Antihypertensive Drug, Antidiabetic Drug, Anticancer Drug
2023 · cited by 4
This review documents specific severe interactions, noting that Ginkgo biloba combined with prescription drugs like trazodone can lead to serious adverse events.
The paper trail · every fact has a biography
first checked04 Aug 2026
judged → SUPPORTED · 8504 Aug 2026
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