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the claim
External electric fields can inhibit tumor growth by disrupting cell division
the verdict
SUPPORTED
the evidence backs this
Recorded sources
8 sources for · 0 against
Is it true that external electric fields can inhibit tumor growth by disrupting cell division?
Yes. Multiple studies demonstrate that external electric fields, such as Tumor Treating Fields (TTFields), inhibit tumor growth by interfering with cell division, disrupting mitotic structures, and inducing apoptosis.
Verdict: SUPPORTED · 8 sources for, 0 against · Last checked
The analysis
The retrieved papers consistently report that external electric fields (TTFields and pulsed fields) exert anti-mitotic effects on various cancer cells, disrupting cell division and inhibiting tumor growth. There is no contradictory evidence in the provided sources.
Evidence for · 8
Demonstrates that Tumor Treating Fields (TTFields) disrupt mitotic spindle assembly and cause apoptosis in cancer cells.
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Giladi, M., Schneiderman, R. S., Voloshin, T., Porat, Y., Munster, M., Blat, R., Sherbo, S., Bomzon, Z., Urman, N., Itzhaki, A., Cahal, S., Shteingauz, A., Chaudhry, A., Kirson, E. D., Weinberg, U., & Palti, Y. (2015). Mitotic Spindle Disruption by Alternating Electric Fields Leads to Improper Chromosome Segregation and Mitotic Catastrophe in Cancer Cells. doi.org. https://doi.org/10.1038/srep18046
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More for · 7
Investigates the anti-cancer efficacy of tumor electric field therapy against glioblastoma models.
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Wu, H., Yang, L., Liu, H., Zhou, D., Chen, D., Zheng, X., Yang, H., Li, C., Chang, J., Wu, A., Wang, Z., Ren, N., Lv, S., Liu, Y., Jia, M., Lu, J., Liu, H., Sun, G., Liu, Z., Liu, J., & Chen, L. (2021). Exploring the efficacy of tumor electric field therapy against glioblastoma: An in vivo and in vitro study. doi.org. https://doi.org/10.1111/cns.13750
Shows that tumor-treating electric fields induce anti-proliferative effects on mitotic cells in various cancers.
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Smothers, A. R., Henderson, J. R., O’Connell, J. J., Stenbeck, J. M., Dean, D., Harvey, T. G., & Booth, B. (2023). Efficacy and selectivity of tumor-treating field therapy for triple-negative breast cancer cells via in-house delivery device. doi.org. https://doi.org/10.1007/s12672-023-00647-w
Reports that TTFields exert antimitotic effects, impairing cancer cell proliferation and clonogenicity.
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Y, Y., Y, W., J, F., M, Y., & Y, S. (2025). Tumor treating fields suppress tumor cell growth and induce immunogenic cell death biomarkers in biliary tract cancer cell lines.. doi.org. https://doi.org/10.1038/s41598-025-16341-6
Demonstrates that modulated electric fields effectively induce apoptosis and combat cancer cell growth during mitosis.
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Smothers, A. R., Henderson, J. R., O’Connell, J. J., Stenbeck, J. M., Dean, D., & Booth, B. (2023). Optimization of tumor-treating field therapy for triple-negative breast cancer cells in vitro via frequency modulation. doi.org. https://doi.org/10.1186/s12935-023-02959-x
Explains how Tumor Treating Fields produce physical and mechanical disruptions to inhibit tumor progression.
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X, M., Z, Z., Y, S., & H, A. (2026). Tumor treating fields in malignant pleural mesothelioma: from cytoskeletal collapse to immunophenotypic conversion.. doi.org. https://doi.org/10.3389/fimmu.2026.1782708
Shows that TTFields inhibit tumor growth by disrupting mitosis and causing microtubule and metabolic aberrations.
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Z, S., M, L., M, K., J, O., S, S., O, H., M, F., T, G., C, S., & M, L. (2026). NAALADL1 modulates cellular resistance to Tumor Treating Fields in colorectal cancer.. doi.org. https://doi.org/10.1038/s41698-026-01492-0
Summarizes the use of low-intensity alternating electric fields to disrupt mitotic processes and induce cancer cell death.
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D, A., HK, R., I, S., S, B., D, M., & HM, B. (2026). Combining Tumor Treating Fields with Immunotherapy in Pancreatic Ductal Adenocarcinoma: Mechanisms, Preclinical Evidence, and Emerging Therapeutic Synergy.. doi.org. https://doi.org/10.3390/cells15090845
What does the evidence say?
The retrieved papers consistently report that external electric fields (TTFields and pulsed fields) exert anti-mitotic effects on various cancer cells, disrupting cell division and inhibiting tumor growth. There is no contradictory evidence in the provided sources.
Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 9004 Aug 2026
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