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the claim

Epithelial cells undergo cell cycle arrest when exposed to serum deprivation.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
3 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Epithelial cells undergo cell cycle arrest when exposed to serum deprivation?

Yes. Multiple studies demonstrate that epithelial cells undergo cell cycle arrest or enter quiescence when subjected to serum deprivation.

Verdict: SUPPORTED · 3 sources for, 0 against · Last checked

The analysis

The claim is a specific, contestable, and well-supported empirical statement about cellular biology. Multiple retrieved papers explicitly demonstrate that epithelial cells (such as retinal pigment epithelial cells and ovarian cancer cells) undergo cell cycle arrest (such as G0/G1 arrest) when subjected to serum starvation, with none of the provided papers refuting this physiological response.

Evidence for · 3
Growth stimulation leads to cellular senescence when the cell cycle is blocked
2008
Serum starvation in human epithelial cells (like RPE cells) caused quiescence and cell cycle arrest.
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Demidenko, Z. & Blagosklonny, M. V. (2008). Growth stimulation leads to cellular senescence when the cell cycle is blocked. doi.org. https://doi.org/10.4161/cc.7.21.6919

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More for · 2
Tumor-infiltrating bacteria disrupt cancer epithelial cell interactions and induce cell-cycle arrest
2025
Extracellular intratumoral bacteria induced G0-G1 arrest and transcriptional quiescence in epithelial cells in vitro.
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Niño, J. L. G., Ponath, F., Ajisafe, V. A., Becker, C., Kempchinsky, A. G., Zepeda-Rivera, M. A., Gomez, J. A., Wu, H., Terrazas, J. G., Bouzek, H. K., Cromwell, E., Chanana, P., Wong, M., Damania, A. V., White, M. G., You, Y. N., Kopetz, S., Ajami, N., Wargo, J., Johnston, C. D., & Bullman, S. (2025). Tumor-infiltrating bacteria disrupt cancer epithelial cell interactions and induce cell-cycle arrest. doi.org. https://doi.org/10.1016/j.ccell.2025.09.010

Serum starvation-based method of ovarian cancer cell dormancy induction and termination in vitro
2023
Serum starvation induced G0/G1 growth arrest in epithelial ovarian cancer cells without causing apoptosis.
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Rutecki, S., Leśniewska-Bocianowska, A., Chmielewska, K., Matuszewska, J., Naumowicz, E., Uruski, P., Radziemski, A., Mikuła-Pietrasik, J., Tykarski, A., & Książek, K. (2023). Serum starvation-based method of ovarian cancer cell dormancy induction and termination in vitro. doi.org. https://doi.org/10.1093/biomethods/bpad029

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What does the evidence say?

The claim is a specific, contestable, and well-supported empirical statement about cellular biology. Multiple retrieved papers explicitly demonstrate that epithelial cells (such as retinal pigment epithelial cells and ovarian cancer cells) undergo cell cycle arrest (such as G0/G1 arrest) when subjected to serum starvation, with none of the provided papers refuting this physiological response.

Receipt History
first checked04 Aug 2026
judged → SUPPORTED · 9104 Aug 2026
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