Environmental factors alter gene expression in humans through epigenetic mechanisms
Is it true that environmental factors alter gene expression in humans through epigenetic mechanisms?
Yes. Substantial scientific literature establishes that environmental factors such as diet, lifestyle, and toxins alter human gene expression through epigenetic mechanisms including DNA methylation and histone modification.
Verdict: SUPPORTED · 9 sources for, 0 against · Last checked
The retrieved papers overwhelmingly support the claim that environmental factors alter gene expression through epigenetic mechanisms. Multiple reviews and empirical studies (e.g., [0], [1], [2], [3], [5], [6], [7], [8], [10]) document how dietary components, stress, lifestyle, and other environmental exposures induce epigenetic modifications (such as DNA methylation, histone modifications, and non-coding RNA regulation) that impact gene expression and disease risk. There are no papers refuting this well-established biological principle.
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Maleknia, M., Ahmadirad, N., Golab, F., Katebi, Y., & Ketabforoush, A. H. M. E. (2023). DNA Methylation in Cancer: Epigenetic View of Dietary and Lifestyle Factors. doi.org. https://doi.org/10.1177/25168657231199893
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Nicoletti, C. F., Assmann, T. S., Souza, L. L., & Martinez, J. A. (2024). DNA Methylation and Non-Coding RNAs in Metabolic Disorders: Epigenetic Role of Nutrients, Dietary Patterns, and Weight Loss Interventions for Precision Nutrition. doi.org. https://doi.org/10.1159/000541000
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Yesayan, A., Chetta, M., Babayan, B., Yesayan, T., Esoyan, S., & Sevoyan, G. G. (2024). The epigenetic impact of daily diet food choices on human health and chronic diseases. doi.org. https://doi.org/10.31989/ffhd.v14i10.1464
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KM, G., P, C., & S, E. (2025). Nutrition in early life, epigenetics and lifelong health - evidence from cohort and intervention studies.. doi.org. https://doi.org/10.1017/s0029665125102061
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F, M. & A, S. (2026). Climate Change, Epigenetics, Microbiota, and Health.. doi.org. https://doi.org/10.3390/ijerph23030388
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Servushan, P. (2023). Epigenetics and Disease: How Environmental Factors Impact Gene Expression. doi.org. https://doi.org/10.31219/osf.io/64szm
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A, B., M, Q., K, K., M, D. P. B., H, V., S, G., S, J., S, C., M, W., E, G., L, K., & C, F. (2026). Unraveling the complexity of skin's biological aging utilizing epigenetic clocks.. doi.org. https://doi.org/10.1186/s13148-026-02101-4
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HJ, H. & RC, F. (2026). Epigenetic mechanisms linking the perinatal environment, the placenta, and maternal and child health outcomes: evidence for sexual dimorphism.. doi.org. https://doi.org/10.1093/eep/dvag012
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C, H., CL, M., T, A., D, S., & SK, M. (2026). Environmental exposures and epigenetic alterations in common chronic diseases: insights and challenges.. doi.org. https://doi.org/10.1093/eep/dvag014
What does the evidence say?
The retrieved papers overwhelmingly support the claim that environmental factors alter gene expression through epigenetic mechanisms. Multiple reviews and empirical studies (e.g., [0], [1], [2], [3], [5], [6], [7], [8], [10]) document how dietary components, stress, lifestyle, and other environmental exposures induce epigenetic modifications (such as DNA methylation, histone modifications, and non-coding RNA regulation) that impact gene expression and disease risk. There are no papers refuting this well-established biological principle.
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