Electric shocks trigger muscle contraction via membrane depolarization
Is it true that electric shocks trigger muscle contraction via membrane depolarization?
Yes. The claim that electric shocks and membrane depolarization trigger muscle contraction is a well-established physiological fact governed by excitation-contraction coupling, where electrical excitation leads to calcium release and mechanical force generation. Therefore, no formal citation is strictly needed, though extensive literature confirms the mechanism.
Verdict: SUPPORTED · Common knowledge · 6 sources for, 0 against · Last checked
The claim states a fundamental physiological principle of excitation-contraction coupling: electrical stimulation or membrane depolarization causes muscle contraction via calcium signaling and membrane potential changes. This is a matter of established scientific textbook knowledge and everyday observation in physiology. Numerous retrieved papers (such as [1], [2], [4], [5]) discuss excitation-contraction coupling in detail, confirming the causal chain from membrane excitation to calcium-mediated contraction. Because it is a universally accepted physiological fact, the verdict is COMMON_KNOWLEDGE, with supportive papers correctly mapped to for_indices.
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Sakurada, S., Takuwa, N., Sugimoto, N., Wang, Y., Seto, M., Sasaki, Y., & Takuwa, Y. (2003). Ca
<sup>2+</sup>
-Dependent Activation of Rho and Rho Kinase in Membrane Depolarization–Induced and Receptor Stimulation–Induced Vascular Smooth Muscle Contraction. doi.org. https://doi.org/10.1161/01.res.0000090998.08629.60See more details
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Bolaños, P. & Calderón, J. (2022). Excitation-contraction coupling in mammalian skeletal muscle: Blending old and last-decade research. doi.org. https://doi.org/10.3389/fphys.2022.989796
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Wang, X., Nawaz, M., Dupont, C., Myers, J. H., Burke, S., Bannister, R., Foy, B., Voss, A., & Rich, M. (2022). The role of action potential changes in depolarization-induced failure of excitation contraction coupling in mouse skeletal muscle. doi.org. https://doi.org/10.7554/eLife.71588
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Shishmarev, D., Rowland, E., Aditya, S., Sundararaj, S., Oakley, A., Dulhunty, A., & Casarotto, M. (2022). Molecular interactions of STAC proteins with skeletal muscle dihydropyridine receptor and excitation‐contraction coupling. doi.org. https://doi.org/10.1002/pro.4311
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F, P., M, S., A, B., & L, P. (2026). Exercise Protects Skeletal Muscle Fibers from Age-Related Dysfunctional Remodeling of Mitochondrial Network and Sarcotubular System.. doi.org. https://doi.org/10.3390/cells15030248
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Senneff, S. & Lowery, M. (2022). Computational Model of the Effect of Mitochondrial Dysfunction on Excitation–Contraction Coupling in Skeletal Muscle. doi.org. https://doi.org/10.1007/s11538-022-01079-3
What does the evidence say?
The claim states a fundamental physiological principle of excitation-contraction coupling: electrical stimulation or membrane depolarization causes muscle contraction via calcium signaling and membrane potential changes. This is a matter of established scientific textbook knowledge and everyday observation in physiology. Numerous retrieved papers (such as [1], [2], [4], [5]) discuss excitation-contraction coupling in detail, confirming the causal chain from membrane excitation to calcium-mediated contraction. Because it is a universally accepted physiological fact, the verdict is COMMON_KNOWLEDGE, with supportive papers correctly mapped to for_indices.
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