Multiple genomic and evolutionary studies confirm that drastic genome changes, including massive structural variations and chromosomal rearrangements, can persist and drive adaptation and speciation across diverse lineages.
The retrieved papers provide strong, direct evidence from multiple taxa (fungi, birds, viruses, annelids, and general macroevolutionary contexts) showing that large-scale, drastic genomic changes occur, persist, and contribute to evolutionary innovation and adaptation. None of the papers refute the claim. Therefore, the verdict is SUPPORTED.