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the claim
Double spike isotopic standards are suitable for quantification by isotope dilution mass spectrometry
the verdict
SUPPORTED
the evidence backs this
refutedsupported
the weight of evidence
2 sources for · 0 against

Double spike isotopic standards and associated isotope dilution mass spectrometry methods are demonstrated to be accurate and suitable for precise quantitative chemical analysis.

Evidence for · 2
Comparison of calibration strategies for accurate quantitation by isotope dilution mass spectrometry: a case study of ochratoxin A in flour.
2024 · cited by 6
Demonstrates that double isotope dilution mass spectrometry (ID2MS) accurately quantifies ochratoxin A in flour, falling within expected ranges for certified reference materials.
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The analysis

The retrieved papers include studies specifically investigating double isotope dilution mass spectrometry (ID2MS) and double-spike isotope dilution techniques. These papers validate the high accuracy and suitability of double-spike isotopic standards for quantification tasks such as analyzing mycotoxins in food and creatinine in serum. No papers refute the claim.

More for · 1
CORRECTION OF CREATINE-CREATININE CONVERSION DURING SERUM CREATININE QUANTIFICATION BY TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY AND DOUBLE-SPIKE ISOTOPE DILUTION TANDEM MASS SPECTROMETRY.
2024 · cited by 4
Develops and validates a candidate reference method using double-spike isotope dilution tandem mass spectrometry for accurate serum creatinine quantification.
Everything we examined (12)
We also searched for evidence AGAINST this claim, not only for it.
  1. Recommendations for the Generation, Quantification, Storage, and Handling of Peptides Used for Mass Spectrometry-Based Assays.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  2. Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  3. A Platform for Discovery and Quantification of Modified Ribonucleosides in RNA: Application to Stress-Induced Reprogramming of tRNA Modifications.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  4. Four-dimensional trapped ion mobility spectrometry lipidomics for high throughput clinical profiling of human blood samples.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  5. Calibration Practices in Clinical Mass Spectrometry: Review and Recommendations.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  6. Practical Guide to Measuring Wetland Carbon Pools and Fluxes.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  7. Online Solid Phase Extraction High-Performance Liquid Chromatography – Isotope Dilution – Tandem Mass Spectrometry Quantification of Organophosphate Pesticides, Synthetic Pyrethroids, and Selected Herbicide Metabolites ipeer-reviewedno side takennot shown: read and judged not to bear on this claim
  8. Quantification of tributyltin in seawater using triple isotope dilution gas chromatography-inductively coupled plasma mass spectrometry achieving high accuracy and complying with European Water Framework Directive limitspeer-reviewedno side takennot shown: read and judged not to bear on this claim
  9. Comparison of calibration strategies for accurate quantitation by isotope dilution mass spectrometry: a case study of ochratoxin A in flour.peer-reviewedsupports
  10. CORRECTION OF CREATINE-CREATININE CONVERSION DURING SERUM CREATININE QUANTIFICATION BY TWO-DIMENSIONAL LIQUID CHROMATOGRAPHY AND DOUBLE-SPIKE ISOTOPE DILUTION TANDEM MASS SPECTROMETRY.peer-reviewedsupports
  11. An Offline SPE-LC-MS/MS Method for Simultaneous Quantification of Tacrolimus, Cyclosporine A, Kynurenine, Tryptophan, and Creatinine Using Volumetric Absorptive Microsampling Device Mitra.peer-reviewedno side takennot shown: read and judged not to bear on this claim
  12. Environmental behavior and human health risks of PFAS: occurrence, toxicity, and the state-of-the-art removal approaches.peer-reviewedno side takennot shown: read and judged not to bear on this claim
The paper trail · every fact has a biography
first checked05 Aug 2026
judged → SUPPORTED · 6905 Aug 2026
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