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the claim

Dihydrofolate reductase functions in humans by reducing dihydrofolate to tetrahydrofolate

the verdict
SUPPORTED
the evidence backs this
Recorded sources
2 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that Dihydrofolate reductase functions in humans by reducing dihydrofolate to tetrahydrofolate?

Yes. Dihydrofolate reductase functions to reduce dihydrofolate to tetrahydrofolate, a vital process for cellular one-carbon metabolism and cofactor availability.

Verdict: SUPPORTED · 2 sources for, 0 against · Last checked

The analysis

The claim states that dihydrofolate reductase functions by reducing dihydrofolate to tetrahydrofolate. Papers 6 and 11 explicitly support the biochemical function of dihydrofolate reductase (DHFR) in reducing dihydrofolate (or related pterins) to the tetrahydro form (tetrahydrofolate) to serve as a cellular cofactor. No retrieved papers refute this fundamental biochemical role.

Evidence for · 2
DHFR2 RNA directly regulates dihydrofolate reductase and its expression level impacts folate one carbon metabolism.
2025
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P, D., N, B., KY, L., M, H., P, M., NDE, G., & A, P. (2025). DHFR2 RNA directly regulates dihydrofolate reductase and its expression level impacts folate one carbon metabolism.. doi.org. https://doi.org/10.1096/fj.202401039rr

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More for · 1
Mechanism of auranofin toxicity: Inhibition of tetrahydrobiopterin metabolism.
2026
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S, Y., YH, J., JR, R., DE, H., & JD, L. (2026). Mechanism of auranofin toxicity: Inhibition of tetrahydrobiopterin metabolism.. doi.org. https://doi.org/10.1016/j.taap.2025.117615

Receipt History
first checked05 Aug 2026
judged → SUPPORTED · 7805 Aug 2026
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