trustmebro.to/r/…
✓ checked
trust me, bro:
here is the receipt.
the claim

Differences in pKa values directly correlate with changes in chemical reactivity.

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that differences in pKa values directly correlate with changes in chemical reactivity?

Yes. Differences in pKa and related thermodynamic acidity parameters consistently govern chemical reactivity and reaction kinetics across various molecular systems.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked

The analysis

The retrieved literature consistently supports the chemical principle that changes in acidity, proton-coupled thermodynamics, and related structural parameters directly dictate reaction rates and chemical reactivity trends. Papers [0], [1], [2], and [6] explicitly demonstrate the quantitative relationships between acid-base/thermodynamic properties and kinetic or reactivity outcomes. No papers refute this principle.

Evidence for · 4
Multisite Proton-Coupled Electron Transfer at a Keggin-Type Polyoxotungstate.
2026
Demonstrates that tuning effective bond dissociation free energies via proton-coupled electron transfer enables controlled oxidative and reductive hydrogen atom transfer reactivity.
Get citation
Z, L., HA, G., & EM, M. (2026). Multisite Proton-Coupled Electron Transfer at a Keggin-Type Polyoxotungstate.. doi.org. https://doi.org/10.1021/jacs.5c18764

See more details
More for · 3
Electronic and Steric Tuning of Molecular Acidity toward Unified Models for Excited State Proton Transfer.
2026
Shows that the thermodynamic driving force governed by electronic and steric effects directly dictates excited-state proton transfer kinetics.
Get citation
C, C., IN, M., MS, B., & C, F. (2026). Electronic and Steric Tuning of Molecular Acidity toward Unified Models for Excited State Proton Transfer.. doi.org. https://doi.org/10.1002/advs.202517140

<i>ortho</i>-Substituents govern aryl aldehyde reactivity: toward lysine-targeted, tunable inhibitors of glucose-6-phosphate dehydrogenase.
2026
Establishes that structural modifications that alter acidity and stabilization in aryl aldehydes directly correlate with reaction kinetics and inhibitor potency.
Get citation
BE, R., KD, R., A, A., M, B., T, K., JC, F., AJ, N., E, O., & DL, J. (2026). <i>ortho</i>-Substituents govern aryl aldehyde reactivity: toward lysine-targeted, tunable inhibitors of glucose-6-phosphate dehydrogenase.. doi.org. https://doi.org/10.1039/d6cb00070c

Comparative Review of <i>O</i>,<i>O</i>'-, <i>N</i>,<i>O</i>-, and <i>N</i>,<i>N</i>'-Bidentate Ligands: Structural and Electronic Properties of β-Diketones, Enaminones, and β-Diketiminates.
2026
Indicates that systematic substitution within a conserved scaffold provides a way to tune acidity and corresponding redox or coordination reactivity.
Get citation
J, C. (2026). Comparative Review of <i>O</i>,<i>O</i>'-, <i>N</i>,<i>O</i>-, and <i>N</i>,<i>N</i>'-Bidentate Ligands: Structural and Electronic Properties of β-Diketones, Enaminones, and β-Diketiminates.. doi.org. https://doi.org/10.3390/molecules31071223

Related receipts
Receipt History
first checked05 Aug 2026
judged → SUPPORTED · 7705 Aug 2026
Anyone with this link can read the claim and its public receipt, including any personal information in that text. Open permanent receipt.
Check your own claim
Challenge the receipt
Requests are recorded for review. This does not start an automatic check or guarantee a response time.

See the evidence timeline

Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.

This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work