✓ checked
trust me, bro:
here is the receipt.
the claim
Compounds can be soluble in solvent mixtures while insoluble in the individual pure solvents
the verdict
SUPPORTED
the evidence backs this
Recorded sources
7 sources for · 0 against
Is it true that compounds can be soluble in solvent mixtures while insoluble in the individual pure solvents?
Yes. Compounds frequently exhibit a strong cosolvency effect, displaying significantly higher solubility in specific solvent mixtures than in any of the individual pure components alone.
Verdict: SUPPORTED · 7 sources for, 0 against · Last checked
The analysis
The retrieved literature extensively covers cosolvency, demonstrating that many compounds have a solubility peak in binary or ternary solvent mixtures that far exceeds their solubility in the respective pure individual solvents.
Evidence for · 7
Reviews how cosolvency models predict enhanced solubility in solvent mixtures compared to individual solvents.
Get citation
Jouyban, A. (2008). Review of the cosolvency models for predicting solubility of drugs in water-cosolvent mixtures. doi.org. https://doi.org/10.18433/j3pp4k
See more details
More for · 6
Examines how binary solvent mixtures like ethanol and propylene glycol alter drug solubility profiles.
Get citation
Vahdati, S., Shayanfar, A., Hanaee, J., Martínez, F., Acree, W. E., & Jouyban, A. (2013). Solubility of Carvedilol in Ethanol + Propylene Glycol Mixtures at Various Temperatures. doi.org. https://doi.org/10.1021/ie403054z
Demonstrates the cosolvency approach where solvent blends significantly increase solute solubility.
Get citation
Nayak, A. K. & Panigrahi, P. P. (2012). Solubility Enhancement of Etoricoxib by Cosolvency Approach. doi.org. https://doi.org/10.5402/2012/820653
Discusses various linear and non-linear cosolvency models demonstrating enhanced solubilization in mixed solvents.
Get citation
Jouyban, A., Chew, N. Y., Chan, H., Sabour, M., & Acree, W. E. (2005). A Unified Cosolvency Model for Calculating Solute Solubility in Mixed Solvents. doi.org. https://doi.org/10.1248/cpb.53.634
Reports that minocycline hydrochloride solubility increases dramatically in solvent mixtures compared to individual pure solvents.
Get citation
Li, R., Yin, X., Jin, Y., Chen, X., Zhao, B., Wang, W., Zhong, S., & Han, D. (2021). The solubility profile and dissolution thermodynamic properties of minocycline hydrochloride in some pure and mixed solvents at several temperatures. doi.org. https://doi.org/10.1016/J.JCT.2021.106399
Observes that aripiprazole exhibits a solubility maximum in mixed solvents compared to pure components.
Get citation
Wu, Y., Cheng, L., Wu, J., Zhai, M., & Cai, L. (2019). Cosolvent effect on solubility of aripiprazole in mixed solvents and apparent thermodynamic analysis of dissolution process. doi.org. https://doi.org/10.1016/J.JCT.2019.03.021
Shows strong cosolvency effects where binary solvent mixtures yield higher solubility than individual pure components.
Get citation
Jeliński, T., Kubsik, M., & Cysewski, P. (2022). Application of the Solute–Solvent Intermolecular Interactions as Indicator of Caffeine Solubility in Aqueous Binary Aprotic and Proton Acceptor Solvents: Measurements and Quantum Chemistry Computations. doi.org. https://doi.org/10.3390/ma15072472
What does the evidence say?
The retrieved literature extensively covers cosolvency, demonstrating that many compounds have a solubility peak in binary or ternary solvent mixtures that far exceeds their solubility in the respective pure individual solvents.
Receipt History
first checked31 Jul 2026
judged → SUPPORTED · 9331 Jul 2026
Anyone with this link can read the claim and its public receipt, including any
personal information in that text. Open permanent receipt.
Check your own claim
Challenge the receipt
Requests are recorded for review. This does not start an automatic check
or guarantee a response time.
Citation formatting by citeproc-js (Frank Bennett) and the Citation Style Language project. Source and licenses.
This receipt is an automated verdict against our published method · not an opinion about any author or publication.
Terms · Privacy · How verdicts work
Terms · Privacy · How verdicts work