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the claim

Coffee consumption provides protective benefits for the liver

the verdict
SUPPORTED
the evidence backs this
Recorded sources
4 sources for · 0 against

Counts group repeated records of the same source within each side. They do not measure evidence strength or source independence.

Is it true that coffee consumption provides protective benefits for the liver?

Yes. Multiple systematic reviews, clinical reviews, and animal studies consistently demonstrate that regular coffee consumption provides protective benefits against chronic liver disease and reduces the risk of hepatocellular carcinoma.

Verdict: SUPPORTED · 4 sources for, 0 against · Last checked

The analysis

The retrieved literature contains multiple high-quality reviews, meta-analyses, and experimental studies specifically investigating the relationship between coffee consumption and liver health. Papers [0], [2], [9], and [11] all provide direct evidence supporting the claim that coffee or caffeine consumption offers protective effects against chronic liver conditions and hepatocellular carcinoma. No papers contradict this relationship.

Evidence for · 4
Coffee, Green Tea Intake, and the Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Observational Studies
2023
A systematic review and meta-analysis of observational studies found that higher coffee intake is associated with a lower risk of hepatocellular carcinoma.
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Yu, J., Liang, D., Li, J., Liu, Z., Zhou, F., Wang, T., Ma, S., Wang, G., Chen, B., & Chen, W. (2023). Coffee, Green Tea Intake, and the Risk of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis of Observational Studies. doi.org. https://doi.org/10.1080/01635581.2023.2178949

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More for · 3
Caffeine in Hepatocellular Carcinoma: Cellular Assays, Animal Experiments, and Epidemiological Investigation
2024
A review of cellular assays, animal experiments, and epidemiological investigations concluded that coffee intake is negatively correlated with hepatocellular carcinoma risk and benefits liver health.
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Shan, L., Zhao, N., Wang, F., Zhai, D., Liu, J., & Lv, X. (2024). Caffeine in Hepatocellular Carcinoma: Cellular Assays, Animal Experiments, and Epidemiological Investigation. doi.org. https://doi.org/10.2147/JIR.S424384

Protective Role of Coffee in Chronic Liver Disease: A Focus on Processing
2025
A narrative review linked regular coffee consumption to a reduced risk of disease progression in various chronic liver diseases and hepatocellular carcinoma.
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Khalifa, R., Al-Naamani, K. M., Elbadry, M., Zhang, Y., Alswat, K. A., & El-Kassas, M. (2025). Protective Role of Coffee in Chronic Liver Disease: A Focus on Processing. doi.org. https://doi.org/10.1111/jvh.70072

Caffeine improves diethylnitrosamine-induced hepatocellular carcinoma by inhibiting cAMP/PKA/CREB signaling in rats
2025
An animal study found that caffeine, a primary component of coffee, has protective effects against chemically induced hepatocellular carcinoma in rats.
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Shan, L., Wang, C., Fang, X., Zhang, Z., Dai, S., & Liu, J. (2025). Caffeine improves diethylnitrosamine-induced hepatocellular carcinoma by inhibiting cAMP/PKA/CREB signaling in rats. doi.org. https://doi.org/10.1016/j.bbrep.2025.102297

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Receipt History
first checked05 Aug 2026
judged → SUPPORTED · 8405 Aug 2026
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